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Fältnamn	Indikatorer	Metadata
000		05861naa a2201213 4500
001		oai:DiVA.org:uu-273528
003		SwePub
008		160115s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2735282 URI
024	7	a https://doi.org/10.1002/art.395602 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Liu, Ke4 aut
245	1 0	a X Chromosome Dose and Sex Bias in Autoimmune Diseases :b Increased 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome
264	1	b Wiley,c 2016
338		a print2 rdacarrier
520		a OBJECTIVE:More than 80% of autoimmune disease is female dominant, but the mechanism for this female bias is poorly understood. We suspected an X chromosome dose effect and hypothesized that trisomy X (47,XXX, 1 in ∼1,000 live female births) would be increased in female predominant diseases (e.g. systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis [PBC] and rheumatoid arthritis [RA]) compared to diseases without female predominance (sarcoidosis) and controls.METHODS:We identified 47,XXX subjects using aggregate data from single nucleotide polymorphism (SNP) arrays and confirmed, when possible, by fluorescent in situ hybridization (FISH) or quantitative polymerase chain reaction (q-PCR).RESULTS:We found 47,XXX in seven of 2,826 SLE and three of 1,033 SS female patients, but only in two of the 7,074 female controls (p=0.003, OR=8.78, 95% CI: 1.67-86.79 and p=0.02, OR=10.29, 95% CI: 1.18-123.47; respectively). One 47,XXX subject was present for ∼404 SLE women and ∼344 SS women. 47,XXX was present in excess among SLE and SS subjects.CONCLUSION:The estimated prevalence of SLE and SS in women with 47,XXX was respectively ∼2.5 and ∼2.9 times higher than in 46,XX women and ∼25 and ∼41 times higher than in 46,XY men. No statistically significant increase of 47,XXX was observed in other female-biased diseases (PBC or RA), supporting the idea of multiple pathways to sex bias in autoimmunity. This article is protected by copyright. All rights reserved.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Kurien, Biji T4 aut
700	1	a Zimmerman, Sarah L4 aut
700	1	a Kaufman, Kenneth M4 aut
700	1	a Taft, Diana H4 aut
700	1	a Kottyan, Leah C4 aut
700	1	a Lazaro, Sara4 aut
700	1	a Weaver, Carrie A4 aut
700	1	a Ice, John A4 aut
700	1	a Adler, Adam J4 aut
700	1	a Chodosh, James4 aut
700	1	a Radfar, Lida4 aut
700	1	a Rasmussen, Astrid4 aut
700	1	a Stone, Donald U4 aut
700	1	a Lewis, David M4 aut
700	1	a Li, Shibo4 aut
700	1	a Koelsch, Kristi A4 aut
700	1	a Igoe, Ann4 aut
700	1	a Talsania, Mitali4 aut
700	1	a Kumar, Jay4 aut
700	1	a Maier-Moore, Jacen S4 aut
700	1	a Harris, Valerie M4 aut
700	1	a Gopalakrishnan, Rajaram4 aut
700	1	a Jonsson, Roland4 aut
700	1	a Lessard, James A4 aut
700	1	a Lu, Xianglan4 aut
700	1	a Gottenberg, Jacques-Eric4 aut
700	1	a Anaya, Juan-Manuel4 aut
700	1	a Cunninghame-Graham, Deborah S4 aut
700	1	a Huang, Andrew J W4 aut
700	1	a Brennan, Michael T4 aut
700	1	a Hughes, Pamela4 aut
700	1	a Illei, Gabor G4 aut
700	1	a Miceli-Richard, Corinne4 aut
700	1	a Keystone, Edward C4 aut
700	1	a Bykerk, Vivian P4 aut
700	1	a Hirschfield, Gideon4 aut
700	1	a Xie, Gang4 aut
700	1	a Ng, Wan-Fai4 aut
700	1	a Nordmark, Gunnelu Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Rheumatology4 aut0 (Swepub:uu)gunnnord
700	1	a Eriksson, Per4 aut
700	1	a Omdal, Roald4 aut
700	1	a Rhodus, Nelson L4 aut
700	1	a Rischmueller, Maureen4 aut
700	1	a Rohrer, Michael4 aut
700	1	a Segal, Barbara M4 aut
700	1	a Vyse, Timothy J4 aut
700	1	a Wahren-Herlenius, Marie4 aut
700	1	a Witte, Torsten4 aut
700	1	a Pons-Estel, Bernardo4 aut
700	1	a Alarcon-Riquelme, Marta E4 aut
700	1	a Guthridge, Joel M4 aut
700	1	a James, Judith A4 aut
700	1	a Lessard, Christopher J4 aut
700	1	a Kelly, Jennifer A4 aut
700	1	a Thompson, Susan D4 aut
700	1	a Gaffney, Patrick M4 aut
700	1	a Montgomery, Courtney G4 aut
700	1	a Edberg, Jeffrey C4 aut
700	1	a Kimberly, Robert P4 aut
700	1	a Alarcón, Graciela S4 aut
700	1	a Langefeld, Carl L4 aut
700	1	a Gilkeson, Gary S4 aut
700	1	a Kamen, Diane L4 aut
700	1	a Tsao, Betty P4 aut
700	1	a McCune, W Joseph4 aut
700	1	a Salmon, Jane E4 aut
700	1	a Merrill, Joan T4 aut
700	1	a Weisman, Michael H4 aut
700	1	a Wallace, Daniel J4 aut
700	1	a Utset, Tammy O4 aut
700	1	a Bottinger, Erwin P4 aut
700	1	a Amos, Christopher I4 aut
700	1	a Siminovitch, Katherine A4 aut
700	1	a Mariette, Xavier4 aut
700	1	a Sivils, Kathy L4 aut
700	1	a Harley, John B4 aut
700	1	a Scofield, R Hal4 aut
710	2	a Uppsala universitetb Reumatologi4 org
773	0	t Arthritis & Rheumatologyd : Wileyg 68:5, s. 1290-1300q 68:5<1290-1300x 2326-5191x 2326-5205
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39560
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273528
856	4 8	u https://doi.org/10.1002/art.39560

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Av författaren/redakt...: Liu, Ke; Kurien, Biji T; Zimmerman, Sarah ...; Kaufman, Kenneth ...; Taft, Diana H; Kottyan, Leah C; visa fler...; Lazaro, Sara; Weaver, Carrie A; Ice, John A; Adler, Adam J; Chodosh, James; Radfar, Lida; Rasmussen, Astri ...; Stone, Donald U; Lewis, David M; Li, Shibo; Koelsch, Kristi ...; Igoe, Ann; Talsania, Mitali; Kumar, Jay; Maier-Moore, Jac ...; Harris, Valerie ...; Gopalakrishnan, ...; Jonsson, Roland; Lessard, James A; Lu, Xianglan; Gottenberg, Jacq ...; Anaya, Juan-Manu ...; Cunninghame-Grah ...; Huang, Andrew J ...; Brennan, Michael ...; Hughes, Pamela; Illei, Gabor G; Miceli-Richard, ...; Keystone, Edward ...; Bykerk, Vivian P; Hirschfield, Gid ...; Xie, Gang; Ng, Wan-Fai; Nordmark, Gunnel; Eriksson, Per; Omdal, Roald; Rhodus, Nelson L; Rischmueller, Ma ...; Rohrer, Michael; Segal, Barbara M; Vyse, Timothy J; Wahren-Herlenius ...; Witte, Torsten; Pons-Estel, Bern ...; Alarcon-Riquelme ...; Guthridge, Joel ...; James, Judith A; Lessard, Christo ...; Kelly, Jennifer ...; Thompson, Susan ...; Gaffney, Patrick ...; Montgomery, Cour ...; Edberg, Jeffrey ...; Kimberly, Robert ...; Alarcón, Graciel ...; Langefeld, Carl ...; Gilkeson, Gary S; Kamen, Diane L; Tsao, Betty P; McCune, W Joseph; Salmon, Jane E; Merrill, Joan T; Weisman, Michael ...; Wallace, Daniel ...; Utset, Tammy O; Bottinger, Erwin ...; Amos, Christophe ...; Siminovitch, Kat ...; Mariette, Xavier; Sivils, Kathy L; Harley, John B; Scofield, R Hal; visa färre...

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