A malaria serological map indicating the intersection between parasite antigenic diversity and host antibody repertoires

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Fältnamn	Indikatorer	Metadata
000		03442naa a2200373 4500
001		oai:DiVA.org:su-83793
003		SwePub
008		121214s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-837932 URI
024	7	a https://doi.org/10.1007/s10096-012-1673-z2 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Giha, H. A.4 aut
245	1 0	a A malaria serological map indicating the intersection between parasite antigenic diversity and host antibody repertoires
264		c 2012-06-29
264	1	b Springer Science and Business Media LLC,c 2012
338		a print2 rdacarrier
500		a AuthorCount:7;
520		a A malaria vaccine targeting Plasmodium falciparum remains a strategic goal for malaria control. If a polyvalent vaccine is to be developed, its subunits would probably be chosen based on immunogenicity (concentration of elicited antibodies) and associations of selected antigens with protection. We propose an additional possible selection criterion for the inclusion of subunit antigens; that is, coordination between elicited antibodies. For the quantitative estimation of this coordination, we developed a malaria serological map (MSM). Construction of the MSM was based on three categories of variables: (i) malaria antigens, (ii) total IgG and IgG subclasses, (iii) different sources of plasma. To validate the MSM, in this study, we used four malaria antigens (AMA1, MSP2-3D7, MSP2-FC27 and Pf332-C231) and re-grouped the plasma samples into five pairs of subsets based on age, gender, residence, HbAS and malaria morbidity in 9 years. The plasma total IgG and IgG subclasses to the test antigens were measured, and the whole material was used for the MSM construction. Most of the variables in the MSM were previously tested and their associations with malaria morbidity are known. The coordination of response to each antigens pair in the MSM was quantified as the correlation rate (CR = overall number of significant correlations/total number of correlations x 100 %). Unexpectedly, the results showed that low CRs were mostly associated with variables linked with malaria protection and the antigen eliciting the least CRs was the one associated with protection. The MSM is, thus, of potential value for vaccine design and understanding of malaria natural immunity.
650	7	a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
700	1	a Nasr, A. A.u Stockholms universitet,Wenner-Grens institut4 aut
700	1	a Iriemenam, N. C.u Stockholms universitet,Wenner-Grens institut4 aut
700	1	a Berzins, Klavsu Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)klavs
700	1	a Troye-Blomberg, Maritau Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)marita
700	1	a Arnot, D. E.4 aut
700	1	a ElGhazali, G.4 aut
710	2	a Stockholms universitetb Wenner-Grens institut4 org
773	0	t European Journal of Clinical Microbiology and Infectious Diseasesd : Springer Science and Business Media LLCg 31:11, s. 3117-3125q 31:11<3117-3125x 0934-9723x 1435-4373
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-83793
856	4 8	u https://doi.org/10.1007/s10096-012-1673-z

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Av författaren/redakt...: Giha, H. A.; Nasr, A. A.; Iriemenam, N. C.; Berzins, Klavs; Troye-Blomberg, ...; Arnot, D. E.; visa fler...; ElGhazali, G.; visa färre...

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Av lärosätet: Stockholms universitet

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