SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:1555 3892 OR L773:0963 6897
 

Sökning: L773:1555 3892 OR L773:0963 6897 > Islet Engraftment a...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003432naa a2200361 4500
001oai:DiVA.org:uu-193454
003SwePub
008130204s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:126365022
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1934542 URI
0247 a https://doi.org/10.3727/096368912X6406372 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1263650222 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Molnár, Christianu Karolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
2451 0a Islet Engraftment and Revascularization in Clinical and Experimental Transplantation
264 1c 2013
338 a print2 rdacarrier
520 a Background:Proper revascularization after transplantation is assumed to be crucial forappropriate islet graft function.Methods:We developed a novel non-invasive imagingmethod, based on adenoviral transduction of islets with a hypoxia responsive reporter gene,for continuous in vivo monitoring of hypoxia in islet grafts in a mouse model. In addition,morphological data was obtained from a deceased patient previously subject to intraportaltransplantation.Results:We detected only transient hypoxia in a minority of the animalstransplanted. Importantly, a clear response to hypoxia was observed in vitro after removal ofthe islet-grafts on day twenty-eight after transplantation. Also, the morphological data fromthe deceased patient demonstrated an extensive revascularization of the transplanted islets. Infact, no differences could be seen between native, in pancreas biopsies taken prior to isletisolation, and transplanted islets regarding the number, distribution and shape of the bloodvessels. However, fewer small islets (diameter <39μm) were found in the liver compared to those found in native pancreases. Notably, an absolute majority of the transplanted islets were found remaining within the venous lumen, in direct contact with the vessel wall.Conclusions:In conclusion results presented show less pronounced islet graft hypoxia after subcapsulartransplantation than previously reported using more invasive methods. Also, formation of anextensive intra-islet capillary network, similar to that seen in native islets in the pancreas, wasseen after clinical islet transplantation.
7001 a Essand, Magnusu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)magnessa
7001 a Wennberg, Larsu Karolinska Institutet4 aut
7001 a Berne, Christianu Uppsala universitet,Medicin4 aut0 (Swepub:uu)chber255
7001 a Larsson, Eriku Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)eriklars
7001 a Tufveson, Gunnaru Uppsala universitet,Transplantationskirurgi4 aut0 (Swepub:uu)gutuf839
7001 a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors
7102 a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org
7730 t Cell Transplantationg 22:2, s. 243-251q 22:2<243-251x 0963-6897x 1555-3892
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-193454
8564 8u https://doi.org/10.3727/096368912X640637
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126365022

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy