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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005579naa a2200553 4500
001oai:lup.lub.lu.se:b2bd2a1f-63df-400e-a199-69e0c709c8d1
003SwePub
008161205s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/b2bd2a1f-63df-400e-a199-69e0c709c8d12 URI
0247 a https://doi.org/10.1016/j.eururo.2016.09.0072 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Wit, Esther M Ku Netherlands Cancer Institute4 aut
2451 0a Sentinel Node Procedure in Prostate Cancer : A Systematic Review to Assess Diagnostic Accuracy
264 1b Elsevier BV,c 2017
520 a Context: Extended pelvic lymph node dissection (ePLND) is the gold standard for detecting lymph node (LN) metastases in prostate cancer (PCa). The benefit of sentinel node biopsy (SNB), which is the first draining LN as assessed by imaging of locally injected tracers, remains controversial. Objective: To assess the diagnostic accuracy of SNB in PCa. Evidence acquisition: A systematic literature search of Medline, Embase, and the Cochrane Library (1999-2016) was undertaken using PRISMA guidelines. All studies of SNB in men with PCa using PLND as reference standard were included. The primary outcomes were the nondiagnostic rate (NDR), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and false positive (FP) and false negative (FN) rates. Relevant sensitivity analyses based on SN definitions, ePLND as reference standard, and disease risk were undertaken, including a risk of bias (RoB) assessment. Evidence synthesis: Of 373 articles identified, 21 studies recruiting a total of 2509 patients were eligible for inclusion. Median cumulative percentage (interquartile range) results were 4.1% (1.5-10.7%) for NDR, 95.2% (81.8-100%) for sensitivity, 100% (95.0-100%) for specificity, 100% (87.0-100%) for PPV, 98.0% (94.3-100%) for NPV, 0% (0-5.0%) for the FP rate, and 4.8% (0-18.2%) for the FN rate. The findings did not change significantly on sensitivity analyses. Most studies (17/22) had low RoB for index test and reference standard domains. Conclusions: SNB appears to have diagnostic accuracy comparable to ePLND, with high sensitivity, specificity, PPV and NPV, and a low FN rate. With a low FP rate (rate of detecting positive nodes outside the ePLND template), SNB may not have any additional diagnostic value over and above ePLND, although SNB appears to increase nodal yield by increasing the number of affected nodes when combined with ePLND. Thus, in high-risk disease it may be prudent to combine ePLND with SNB. Patient summary: This literature review showed a high diagnostic accuracy for sentinel node biopsy in detecting positive lymph nodes in prostate cancer, but further studies are needed to explore the effect of sentinel node biopsy on complications and oncologic outcome. The accuracy of sentinel node biopsy (SNB) in detecting positive lymph nodes in prostate cancer appears to have diagnostic accuracy comparable to that of extended pelvic lymph node dissection (ePLND). However, SNB may not have any additional diagnostic value over and above ePLND.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Diagnostic accuracy
653 a Pelvic lymph node dissection
653 a Prostate cancer
653 a Sentinel node
653 a Systematic review
653 a Targeted lymph node biopsy
7001 a Acar, Cenku Eryaman Hospital4 aut
7001 a Grivas, Nikolaosu Netherlands Cancer Institute4 aut
7001 a Yuan, Cathyu University of Aberdeen4 aut
7001 a Horenblas, Simonu Netherlands Cancer Institute4 aut
7001 a Liedberg, Fredriku Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för translationell medicin,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Translational Medicine,Skåne University Hospital4 aut0 (Swepub:lu)urok-fli
7001 a Valdes Olmos, Renato A.u Leiden University Medical Centre4 aut
7001 a van Leeuwen, Fijs W Bu Leiden University Medical Centre4 aut
7001 a van den Berg, Nynke S.u Leiden University Medical Centre4 aut
7001 a Winter, Alexanderu Carl von Ossietzky University of Oldenburg4 aut
7001 a Wawroschek, Friedhelmu Carl von Ossietzky University of Oldenburg4 aut
7001 a Hruby, Stephanu Paracelsus Private Medical University of Salzburg4 aut
7001 a Janetschek, Günteru Paracelsus Private Medical University of Salzburg4 aut
7001 a Vidal-Sicart, Sergiu Hospital Clínic of Barcelona4 aut
7001 a MacLennan, Stevenu University of Aberdeen4 aut
7001 a Lam, Thomas B.u University of Aberdeen4 aut
7001 a van der Poel, Henk G.u Netherlands Cancer Institute4 aut
7102 a Netherlands Cancer Instituteb Eryaman Hospital4 org
7730 t European Urologyd : Elsevier BVg 71:4, s. 596-605q 71:4<596-605x 0302-2838
8564 u http://dx.doi.org/10.1016/j.eururo.2016.09.007y FULLTEXT
8564 u http://hdl.handle.net/2164/9303
8564 8u https://lup.lub.lu.se/record/b2bd2a1f-63df-400e-a199-69e0c709c8d1
8564 8u https://doi.org/10.1016/j.eururo.2016.09.007

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