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Relation among hype...
Relation among hypertriglyceridaemia, cardiometabolic disease, and hereditary factors : design and rationale of the Stockholm hyperTRIglyceridaemia REGister study
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- Andersson, Daniel P. (författare)
- Karolinska Institutet
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- Littmann, Karin (författare)
- Karolinska Institutet
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- Kindborg, Gustav (författare)
- Department of Medicine Huddinge, Karolinska Institutet, Cardio Metabolic Unit, C2:94, Karolinska University Hospital Huddinge, 141 86 Stockholm , Sweden;Medical Unit Endocrinology, C2:94, Karolinska University Hospital Huddinge , 141 86 Stockholm , Sweden
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- Eklund, Daniel (författare)
- Medical Unit Clinical Chemistry, C1-62, Karolinska University Laboratory, 141 86 Stockholm , Sweden
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- Sejersen, Kristina (författare)
- Uppsala universitet,Klinisk kemi,Uppsala University Hospital; Unilabs AB, Unilabs Laboratory Medicine Stockholm, Section of Clinical Chemistry, 171 54 Solna, Sweden
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- Yan, Jane (författare)
- Institute of Environmental Medicine, Unit of Biostatistics, Karolinska Institutet, Nobels väg 13, 17 177 Stockholm , Sweden
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- Eriksson Hogling, Daniel (författare)
- Karolinska Institutet
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- Parini, Paolo (författare)
- Department of Medicine Huddinge, Karolinska Institutet, Cardio Metabolic Unit, C2:94, Karolinska University Hospital Huddinge, 141 86 Stockholm , Sweden;Medical Unit Endocrinology, C2:94, Karolinska University Hospital Huddinge , 141 86 Stockholm , Sweden;Department of Laboratory Medicine, Cardio Metabolic Unit, Karolinska Institutet, Alfred Nobels Allé 8, 141 52 Huddinge , Sweden
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- Brinck, Jonas (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: European Heart Journal Open. - : Oxford University Press. - 2752-4191. ; 4:2
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AimsHypertriglyceridaemia (hTG) is associated with atherosclerotic cardiovascular disease, pancreatitis, and non-alcoholic fatty liver disease (NAFLD) in large population-based studies. The understanding of the impact of hereditary hTG and cardiometabolic disease status on the development of hTG and its associated cardiometabolic outcomes is more limited. We aimed to establish a multigenerational cohort to enable studies of the relationship between hTG, cardiometabolic disease and hereditary factors.Methods and resultsThe population-based observational Stockholm hyperTRIglyceridaemia REGister (STRIREG) study includes 1 460 184 index individuals who have measured plasma triglycerides in the clinical routine in Region Stockholm, Sweden, between 1 January 2000 and 31 December 2021. The laboratory measurements also included basic haematology, blood lipid panel, liver function tests, and HbA1c. Using the Swedish Multi-Generation register, 2 147 635 parents and siblings to the indexes were identified to form the complete study cohort. Laboratory data from participants were combined with data from several national registers that provided information on the cause of death, medical diagnoses, dispensed medicines, and socioeconomic factors including country of birth, education level, and marital status.ConclusionThe multi-generational longitudinal STRIREG cohort provides a unique opportunity to investigate different aspects of hTG as well as heredity for other metabolic diseases. Important outcome measures include mortality, cardiovascular mortality, major cardiovascular events, development of incident diabetes, and NAFLD. The STRIREG study will provide a deeper understanding of the impact of hereditary factors and associated cardiometabolic complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Hypertriglyceridaemia
- Dyslipidaemia
- Cardiovascular disease
- Cardiometabolic disease
- Pancreatitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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