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Glutamate decarboxy...
Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring
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- Ivarsson, Sten-A. (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Ackefors, Malin (författare)
- Uppsala University
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Ekberg, Göran (författare)
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visa fler...
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- Falorni, Alberto (författare)
- Uppsala University
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- Kockum, Ingrid (författare)
- Uppsala University
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- Landin-Olsson, Mona (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Western Washington University
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- Lindberg, Bengt (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sundkvist, Göran (författare)
- Lund University
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- Svanberg, Lars (författare)
- Lund University
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- Carlsson, Annelie (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Autoimmunity,Lund University Research Groups
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska 9 s.
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Ingår i: Autoimmunity. - 0891-6934. ; 26:4, s. 261-269
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmo, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Autoimmunity
- Glutamic acid decarboxylase
- HLA
- Islet cell autoantibodies
- Placental transfer
- Pregnancy
- autoantibody
- enzyme antibody
- glutamate decarboxylase
- pancreas islet cell antibody
- adult
- article
- clinical article
- controlled study
- female
- human
- insulin dependent diabetes mellitus
- non insulin dependent diabetes mellitus
- risk
- Sweden
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ivarsson, Sten-A ...
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Ackefors, Malin
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Ekberg, Göran
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Falorni, Alberto
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Kockum, Ingrid
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Landin-Olsson, M ...
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visa fler...
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Lernmark, Åke
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Lindberg, Bengt
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Sundkvist, Göran
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Svanberg, Lars
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Carlsson, Anneli ...
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visa färre...
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och Klinisk medicin
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Autoimmunity
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Lunds universitet