Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia

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Fältnamn	Indikatorer	Metadata
000		03672naa a2200397 4500
001		oai:lup.lub.lu.se:c00818be-8f78-4971-9802-918c8f78adff
003		SwePub
008		160401s1988 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/11040942 URI
024	7	a https://doi.org/10.3109/088800188090312642 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Dohlsten, M4 aut
245	1 0	a Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia
264		c 2009-07-09
264	1	b Informa UK Limited,c 1988
520		a The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
700	1	a Hedlund, G4 aut
700	1	a Békássy, Albertu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)al4445be
700	1	a Lindén, Olau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-oli
700	1	a Garwicz, Stanislawu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)st6750ga
700	1	a Wiebe, Thomasu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-twi
700	1	a Sjögren, H O4 aut
700	1	a Carlsson, R4 aut
710	2	a Pediatrik, Lundb Sektion V4 org
773	0	t Pediatric Hematology & Oncologyd : Informa UK Limitedg 5:2, s. 143-151q 5:2<143-151x 1521-0669x 0888-0018
856	4	u http://dx.doi.org/10.3109/08880018809031264y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1104094
856	4 8	u https://doi.org/10.3109/08880018809031264

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Av författaren/redakt...: Dohlsten, M; Hedlund, G; Békássy, Albert; Lindén, Ola; Garwicz, Stanisl ...; Wiebe, Thomas; visa fler...; Sjögren, H O; Carlsson, R; visa färre...

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