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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003562naa a2200469 4500
001oai:DiVA.org:uu-430511
003SwePub
008210111s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4305112 URI
0247 a https://doi.org/10.1016/j.envres.2020.1105012 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fu, Xi4 aut
2451 0a Derived habitats of indoor microbes are associated with asthma symptoms in Chinese university dormitories
264 1b Elsevier,c 2021
338 a print2 rdacarrier
520 a Increasing evidence from the home environment indicates that indoor microbiome exposure is associated with asthma development. However, indoor microbiome composition can be highly diverse and dynamic, and thus current studies fail to produce consistent results. Chinese university dormitories are special high-density dwellings with similar building and occupants characteristics, which facilitate to disentangle the complex interactions between microbes, environmental characteristics and asthma. Settled air dust and floor dust was collected from 87 dormitory rooms in Shanxi University. Bacterial communities were characterized by 16 S rRNA amplicon sequencing. Students (n = 357) were surveyed for asthma symptoms and measured for fractional exhaled nitric oxide (FeNO). Asthma was not associated with the overall bacterial richness but associated with specific phylogenetic classes. Taxa richness and abundance in Clostridia, including Ruminococcus, Blautia, Clostridium and Subdoligranulum, were positively associated with asthma (p < 0.05), and these taxa were mainly derived from the human gut. Taxa richness in Alphaproteobacteria and Actinobacteria were marginally protectively associated with asthma, and these taxa were mainly derived from the outdoor environment. Bacterial richness and abundance were not associated with FeNO levels. Building age was associated with overall bacterial community variation in air and floor dust (p < 0.05), but not associated with the asthma-related microorganisms. Our data shows that taxa from different phylogenetic classes and derived habitats have different health effects, indicating the importance of incorporating phylogenetic and ecological concepts in revealing patterns in the microbiome asthma association analysis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a Asthma symptoms
653 a Clostridia
653 a FeNO
653 a Indoor environment
653 a Microbiome
653 a University dormitory
7001 a Li, Yanling4 aut
7001 a Meng, Yi4 aut
7001 a Yuan, Qianqian4 aut
7001 a Zhang, Zefei4 aut
7001 a Wen, Huarong4 aut
7001 a Deng, Yiqun4 aut
7001 a Norbäck, Danu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba
7001 a Hu, Qiansheng4 aut
7001 a Zhang, Xin4 aut
7001 a Sun, Yu4 aut
7102 a Uppsala universitetb Arbets- och miljömedicin4 org
7730 t Environmental Researchd : Elsevierg 194q 194x 0013-9351x 1096-0953
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430511
8564 8u https://doi.org/10.1016/j.envres.2020.110501

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