WFRF:(Liu Hong Min)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02956naa a2200397 4500 | |
| 001 | oai:gup.ub.gu.se/316879 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3168792 URI |
| 024 | 7 | a https://doi.org/10.1039/D2SC00809B2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhu, Wanying4 aut |
| 245 | 1 0 | a Dysfunction of vesicular storage in young-onset Parkinson's patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry |
| 264 | 1 | c 2022 |
| 520 | a Electrochemical cytometry based on nano-tip microelectrodes was used to quantify the vesicular storage at the single-cell level in human neurons and midbrain organoids which acted as disease models of young-onset Parkinson's disease (YOPD). Human dopaminergic (DA) neurons and midbrain organoids were derived from an induced pluripotent stem cell line from one YOPD patient. We show a significant deficiency in vesicular catecholamine storage and a slower pore forming process on the surface of the microelectrode in the DA neurons derived from the YOPD patient. The upregulation of α-synuclein in both neurons and organoids derived from the YOPD patient is associated with vesicular storage dysfunction, revealing a correlation between the pathogenesis of YOPD and vesicular chemical storage deficiency, a novel chemical insight into the potential pathology of YOPD. Notably, efficacy evaluation and drug testing were performed with our platform to demonstrate that both amantadine, a clinical drug for Parkinson's disease (PD), and phorbol 12-myristate 13-acetate, an attractive candidate, ameliorate the dysfunction of vesicular storage in DA neurons derived from the YOPD patient. Our platform offers promising avenues for new drug discovery for PD and other neurodegenerative disorders. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 700 | 1 | a Tao, Mengdan4 aut |
| 700 | 1 | a Hong, Yuan4 aut |
| 700 | 1 | a Wu, Shanshan4 aut |
| 700 | 1 | a Chu, Chu4 aut |
| 700 | 1 | a Zheng, Zhilong4 aut |
| 700 | 1 | a Han, Xiao4 aut |
| 700 | 1 | a Zhu, Qian4 aut |
| 700 | 1 | a Xu, Min4 aut |
| 700 | 1 | a Ewing, Andrew G,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xewian |
| 700 | 1 | a Guo, Xing4 aut |
| 700 | 1 | a Liu, Yan4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Chemical Scienceg 13:21, s. 6217-6223q 13:21<6217-6223x 2041-6520 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/316879 |
| 856 | 4 8 | u https://doi.org/10.1039/D2SC00809B |
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