IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

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Fältnamn	Indikatorer	Metadata
000		05770naa a2201009 4500
001		oai:gup.ub.gu.se/89349
003		SwePub
008		240910s2006 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:1bad217c-126e-4578-9823-8459abfbaadf
024	7	a https://gup.ub.gu.se/publication/893492 URI
024	7	a https://doi.org/10.2337/db06-06002 DOI
024	7	a https://lup.lub.lu.se/record/6860242 URI
040		a (SwePub)gud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Huth, Cornelia4 aut
245	1 0	a IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
264	1	b American Diabetes Association,c 2006
520		a Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, −174G>C (rs1800795) and −573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 −174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 −573G>C and type 2 diabetes. The observed association of the IL6 −174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a body-mass index
653		a interleukin-6 gene
653		a tnf-alpha
653		a -174 g/c
653		a metaanalysis
653		a mellitus
653		a il-6
653		a association
653		a c-174g
653		a plasma
700	1	a Heid, Iris M.4 aut
700	1	a Vollmert, Caren4 aut
700	1	a Gieger, Christian4 aut
700	1	a Grallert, Harald4 aut
700	1	a Wolford, Johanna K.4 aut
700	1	a Langer, Birgit4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Klopp, Norman4 aut
700	1	a Hamid, Yasmin H.4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Hansen, Torben4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Meisinger, Christa4 aut
700	1	a Do?ring, Angela4 aut
700	1	a Lo?wel, Hannelore4 aut
700	1	a Lieb, Wolfgang4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Rathmann, Wolfgang4 aut
700	1	a Martin, Stephan4 aut
700	1	a Stephens, Jeffrey W.4 aut
700	1	a Ireland, Helen4 aut
700	1	a Mather, Hugh4 aut
700	1	a Miller, George J.4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Mo?hlig, Matthias4 aut
700	1	a Spranger, Joachim4 aut
700	1	a Pfeiffer, Andreas4 aut
700	1	a Wernstedt, Ingrid,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwerni
700	1	a Niklason, Anders,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk prövning och entreprenörskap,Institute of Medicine, Department of Clinical Trials and Entrepreneurship4 aut0 (Swepub:gu)xnandz
700	1	a Lo?pez-Bermejo, Abel4 aut
700	1	a Fernández-Real, José-Manuel4 aut
700	1	a Hanson, Robert L.4 aut
700	1	a Gallart, Luis4 aut
700	1	a Vendrell, Joan4 aut
700	1	a Tsiavou, Anastasia4 aut
700	1	a Hatziagelaki, Erifili4 aut
700	1	a Humphries, Steve E.4 aut
700	1	a Wichmann, H.-Erich4 aut
700	1	a Herder, Christian4 aut
700	1	a Illig, Thomas4 aut
700	1	a Doring, Angela4 aut
700	1	a Lowel, Hannelore4 aut
700	1	a Lopez-Bermejo, Abel4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t DIABETESd : American Diabetes Associationg 55:10, s. 2915-2921q 55:10<2915-2921x 0012-1797x 1939-327X
856	4	u http://diabetes.diabetesjournals.org/content/55/10/2915.full.pdf
856	4	u http://dx.doi.org/10.2337/db06-0600x freey FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/89349
856	4 8	u https://doi.org/10.2337/db06-0600
856	4 8	u https://lup.lub.lu.se/record/686024

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Av författaren/redakt...: Huth, Cornelia; Heid, Iris M.; Vollmert, Caren; Gieger, Christia ...; Grallert, Harald; Wolford, Johanna ...; visa fler...; Langer, Birgit; Thorand, Barbara; Klopp, Norman; Hamid, Yasmin H.; Pedersen, Oluf; Hansen, Torben; Lyssenko, Valeri ...; Groop, Leif; Meisinger, Chris ...; Do?ring, Angela; Lo?wel, Hannelor ...; Lieb, Wolfgang; Hengstenberg, Ch ...; Rathmann, Wolfga ...; Martin, Stephan; Stephens, Jeffre ...; Ireland, Helen; Mather, Hugh; Miller, George J ...; Stringham, Heath ...; Boehnke, Michael; Tuomilehto, Jaak ...; Boeing, Heiner; Mo?hlig, Matthia ...; Spranger, Joachi ...; Pfeiffer, Andrea ...; Wernstedt, Ingri ...; Niklason, Anders ...; Lo?pez-Bermejo, ...; Fernández-Real, ...; Hanson, Robert L ...; Gallart, Luis; Vendrell, Joan; Tsiavou, Anastas ...; Hatziagelaki, Er ...; Humphries, Steve ...; Wichmann, H.-Eri ...; Herder, Christia ...; Illig, Thomas; Doring, Angela; Lowel, Hannelore; Lopez-Bermejo, A ...; visa färre...

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