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Divergent metabolic...
Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
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- Murphy, Eileen F. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd., Cork, Ireland
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- Cotter, Paul D. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
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- Hogan, Aileen (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
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- O'Sullivan, Orla (författare)
- Teagasc Food Research Centre, Fermoy, Ireland
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- Joyce, Andy (författare)
- Alimentary Health Ltd., Cork, Ireland
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- Fouhy, Fiona (författare)
- Teagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
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- Clarke, Siobhan F. (författare)
- Teagasc Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
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- Marques, Tatiana M., 1980- (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
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- O'Toole, Paul W. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
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- Stanton, Catherine (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
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- Quigley, Eamonn M. M. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland
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- Daly, Charlie (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
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- Ross, Paul R. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
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- O'Doherty, Robert M. (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh PA, USA
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- Shanahan, Fergus (författare)
- Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, University College Cork, Cork, Ireland
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Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd, Cork, Ireland Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland (creator_code:org_t)
- 2012-02-16
- 2013
- Engelska.
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Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 62:2, s. 220-226
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVE: The gut microbiota is an environmental regulator of fat storage and adiposity. Whether the microbiota represents a realistic therapeutic target for improving metabolic health is unclear. This study explored two antimicrobial strategies for their impact on metabolic abnormalities in murine diet-induced obesity: oral vancomycin and a bacteriocin-producing probiotic (Lactobacillus salivarius UCC118 Bac(+)).DESIGN: Male (7-week-old) C57BL/J6 mice (9-10/group) were fed a low-fat (lean) or a high-fat diet for 20 weeks with/without vancomycin by gavage at 2 mg/day, or with L. salivarius UCC118Bac(+) or the bacteriocin-negative derivative L. salivarius UCC118Bac(-) (each at a dose of 1×10(9) cfu/day by gavage). Compositional analysis of the microbiota was by 16S rDNA amplicon pyrosequencing.RESULTS: Analysis of the gut microbiota showed that vancomycin treatment led to significant reductions in the proportions of Firmicutes and Bacteroidetes and a dramatic increase in Proteobacteria, with no change in Actinobacteria. Vancomycin-treated high-fat-fed mice gained less weight over the intervention period despite similar caloric intake, and had lower fasting blood glucose, plasma TNFα and triglyceride levels compared with diet-induced obese controls. The bacteriocin-producing probiotic had no significant impact on the proportions of Firmicutes but resulted in a relative increase in Bacteroidetes and Proteobacteria and a decrease in Actinobacteria compared with the non-bacteriocin-producing control. No improvement in metabolic profiles was observed in probiotic-fed diet-induced obese mice.CONCLUSION: Both vancomycin and the bacteriocin-producing probiotic altered the gut microbiota in diet-induced obese mice, but in distinct ways. Only vancomycin treatment resulted in an improvement in the metabolic abnormalities associated with obesity thereby establishing that while the gut microbiota is a realistic therapeutic target, the specificity of the antimicrobial agent employed is critical.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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Murphy, Eileen F ...
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Cotter, Paul D.
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Hogan, Aileen
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O'Sullivan, Orla
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Joyce, Andy
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Fouhy, Fiona
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Clarke, Siobhan ...
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Marques, Tatiana ...
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O'Toole, Paul W.
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Stanton, Catheri ...
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Quigley, Eamonn ...
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Daly, Charlie
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Ross, Paul R.
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O'Doherty, Rober ...
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Shanahan, Fergus
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