Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes.

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Adjunctive local antibiotic therapy in the treatment of peri-implantitis II : clinical and radiographic outcomes.

Salvi, Giovanni E (författare): School of Dental Medicine, University of Berne, Berne, Switzerland

Persson, G. Rutger (författare): School of Dental Medicine, University of Berne, Berne, Switzerland

Heitz-Mayfield, Lisa J A (författare): University of Western Australia, Perth, Australia

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Frei, Marc (författare): School of Dental Medicine, University of Berne, Berne, Switzerland

Lang, Niklaus P (författare): School of Dental Medicine, University of Berne, Berne, Switzerland

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(creator_code:org_t)

2007
2007
Engelska.
Ingår i: Clinical Oral Implants Research. - 0905-7161 .- 1600-0501. ; 18:3, s. 281-285

Relaterad länk:: https://doi.org/10.1...

Tidskriftsartikel (refereegranskat)

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AIM: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis.MATERIAL AND METHODS: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) >or=5 mm. Rescue therapy with Arestin was allowed at Days 180 and 270 at any site exhibiting an increase in PPD>or=2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI).RESULTS: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9-2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point.CONCLUSION: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.

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Av författaren/redakt...: Salvi, Giovanni ...; Persson, G. Rutg ...; Heitz-Mayfield, ...; Frei, Marc; Lang, Niklaus P

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

Artiklar i publikationen: Clinical Oral Im ...

Av lärosätet: Högskolan Kristianstad

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Adjunctive local antibiotic therapy in the treatment of peri-implantitis II : clinical and radiographic outcomes.

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