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FältnamnIndikatorerMetadata
00006923naa a2200853 4500
001oai:lup.lub.lu.se:b6152c16-0816-40b6-af19-ae2462ecfdac
003SwePub
008181112s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/b6152c16-0816-40b6-af19-ae2462ecfdac2 URI
0247 a https://doi.org/10.1111/aos.137692 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Meng, Weihuau University of Dundee4 aut
2451 0a A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
264 c 2018-09-04
264 1b Wiley,c 2018
520 a Purpose: Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy. Methods: A genome-wide association approach was applied. In the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) datasets, cases of severe diabetic retinopathy were defined as type 2 diabetic patients who were ever graded as having severe background retinopathy (Level R3) or proliferative retinopathy (Level R4) in at least one eye according to the Scottish Diabetic Retinopathy Grading Scheme or who were once treated by laser photocoagulation. Controls were diabetic individuals whose longitudinal retinopathy screening records were either normal (Level R0) or only with mild background retinopathy (Level R1) in both eyes. Significant Single Nucleotide Polymorphisms (SNPs) were taken forward for meta-analysis using multiple Caucasian cohorts. Results: Five hundred and sixty cases of type 2 diabetes with severe diabetic retinopathy and 4,106 controls were identified in the GoDARTS cohort. We revealed that rs3913535 in the NADPH Oxidase 4 (NOX4) gene reached a p value of 4.05 × 10−9. Two nearby SNPs, rs10765219 and rs11018670 also showed promising p values (p values = 7.41 × 10−8 and 1.23 × 10−8, respectively). In the meta-analysis using multiple Caucasian cohorts (excluding GoDARTS), rs10765219 and rs11018670 showed associations for diabetic retinopathy (p = 0.003 and 0.007, respectively), while the p value of rs3913535 was not significant (p = 0.429). Conclusion: This genome-wide association study of severe diabetic retinopathy suggests new evidence for the involvement of the NOX4 gene.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a diabetes
653 a diabetic complications
653 a diabetic retinopathy
653 a genome-wide association study
653 a NOX4
7001 a Shah, Kaanan P.u University of Chicago4 aut
7001 a Pollack, Samuelau Boston University4 aut
7001 a Toppila, Iirou University of Helsinki,Helsinki University Central Hospital4 aut
7001 a Hebert, Harry L.u University of Dundee4 aut
7001 a McCarthy, Mark I.u University of Oxford,Wellcome Trust Centre for Human Genetics,Churchill Hospital4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Ahlqvist, Emmau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah
7001 a Lyssenko, Valeriyau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
7001 a Agardh, Elisabetu Lund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups4 aut0 (Swepub:lu)ofta-eag
7001 a Daniell, Marku Royal Melbourne Hospital4 aut
7001 a Kaidonis, Georgiau Flinders University4 aut
7001 a Craig, Jamie E.u Flinders University4 aut
7001 a Mitchell, Paulu University of Sydney4 aut
7001 a Liew, Geraldu University of Sydney4 aut
7001 a Kifley, Annetteu University of Sydney4 aut
7001 a Wang, Jie Jinu University of Sydney4 aut
7001 a Christiansen, Mark W.u Washington University School of Medicine4 aut
7001 a Jensen, Richard A.u Washington University School of Medicine4 aut
7001 a Penman, Alanu University of Mississippi Medical Center4 aut
7001 a Hancock, Heather A.u University of Mississippi Medical Center4 aut
7001 a Chen, Ching J.u University of Mississippi Medical Center4 aut
7001 a Correa, Adolfou University of Mississippi Medical Center4 aut
7001 a Kuo, Jane Z.u University of California, Los Angeles,CardioDx Inc.4 aut
7001 a Li, Xiaohuiu University of California, Los Angeles4 aut
7001 a Chen, Yii der I.u University of California, Los Angeles4 aut
7001 a Rotter, Jerome I.u University of California, Los Angeles4 aut
7001 a Klein, Ronaldu University of Wisconsin-Madison4 aut
7001 a Klein, Barbara4 aut
7001 a Wong, Tien Y.u National University of Singapore4 aut
7001 a Morris, Andrew D.u University of Edinburgh4 aut
7001 a Doney, Alexander S.F.u University of Dundee4 aut
7001 a Colhoun, Helen M.u University of Edinburgh4 aut
7001 a Price, Alkes L.u Boston University4 aut
7001 a Burdon, Kathryn P.u University of Tasmania,Flinders University4 aut
7001 a Groop, Per Henriku Helsinki University Central Hospital,Monash University,University of Helsinki4 aut
7001 a Sandholm, Niinau Helsinki University Central Hospital,University of Helsinki4 aut
7001 a Grassi, Michael A.u University of Illinois at Chicago4 aut
7001 a Sobrin, Luciau Harvard Medical School4 aut
7001 a Palmer, Colin N.A.u University of Dundee4 aut
7102 a University of Dundeeb University of Chicago4 org
7102 a Wellcome Trust Case Control Consortium 2 (WTCCC2)
7102 a Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study group
7730 t Acta Ophthalmologicad : Wileyg 96:7, s. 811-819q 96:7<811-819x 1755-375X
8564 u http://dx.doi.org/10.1111/aos.13769x freey FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aos.13769
8564 8u https://lup.lub.lu.se/record/b6152c16-0816-40b6-af19-ae2462ecfdac
8564 8u https://doi.org/10.1111/aos.13769

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