SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Bae Sang Cheol)
 

Search: WFRF:(Bae Sang Cheol) > Clinical associatio...

  • Parker, Ben (author)

Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-09-03
  • BMJ,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:43aad65a-d575-4e2f-8b70-4ef84403c5da
  • https://lup.lub.lu.se/record/3973242URI
  • https://doi.org/10.1136/annrheumdis-2012-202106DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127074773URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS. Methods The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS. Results We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2years (13.4) and 24.1weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS. Conclusions Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Urowitz, Murray B. (author)
  • Gladman, Dafna D. (author)
  • Lunt, Mark (author)
  • Bae, Sang-Cheol (author)
  • Sanchez-Guerrero, Jorge (author)
  • Romero-Diaz, Juanita (author)
  • Gordon, Caroline (author)
  • Wallace, Daniel J. (author)
  • Clarke, Ann E. (author)
  • Bernatsky, Sasha (author)
  • Ginzler, Ellen M. (author)
  • Isenberg, David A. (author)
  • Rahman, Anisur (author)
  • Merrill, Joan T. (author)
  • Alarcon, Graciela S. (author)
  • Fessler, Barri J. (author)
  • Fortin, Paul R. (author)
  • Hanly, John G. (author)
  • Petri, Michelle (author)
  • Steinsson, Kristjan (author)
  • Dooley, Mary-Anne (author)
  • Manzi, Susan (author)
  • Khamashta, Munther A. (author)
  • Ramsey-Goldman, Rosalind (author)
  • Zoma, Asad A. (author)
  • Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
  • Aranow, Cynthia (author)
  • Mackay, Meggan (author)
  • Ramos-Casals, Manuel (author)
  • van Vollenhoven, Raymond F.Karolinska Institutet (author)
  • Kalunian, Kenneth C. (author)
  • Ruiz-Irastorza, Guillermo (author)
  • Lim, Sam (author)
  • Kamen, Diane L. (author)
  • Peschken, Christine A. (author)
  • Inanc, Murat (author)
  • Bruce, Ian N. (author)
  • Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

Related titles

  • In:Annals of the Rheumatic Diseases: BMJ72:8, s. 1308-13141468-20600003-4967

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view