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WFRF:(Bae Sang Cheol)
 

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FältnamnIndikatorerMetadata
00005762naa a2200865 4500
001oai:lup.lub.lu.se:43aad65a-d575-4e2f-8b70-4ef84403c5da
003SwePub
008160401s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:127074773
0247 a https://lup.lub.lu.se/record/39732422 URI
0247 a https://doi.org/10.1136/annrheumdis-2012-2021062 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1270747732 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Parker, Ben4 aut
2451 0a Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort
264 c 2012-09-03
264 1b BMJ,c 2013
520 a Background The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS. Methods The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS. Results We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2years (13.4) and 24.1weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS. Conclusions Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Systemic Lupus Erythematosus
653 a Cardiovascular Disease
653 a Inflammation
653 a Epidemiology
7001 a Urowitz, Murray B.4 aut
7001 a Gladman, Dafna D.4 aut
7001 a Lunt, Mark4 aut
7001 a Bae, Sang-Cheol4 aut
7001 a Sanchez-Guerrero, Jorge4 aut
7001 a Romero-Diaz, Juanita4 aut
7001 a Gordon, Caroline4 aut
7001 a Wallace, Daniel J.4 aut
7001 a Clarke, Ann E.4 aut
7001 a Bernatsky, Sasha4 aut
7001 a Ginzler, Ellen M.4 aut
7001 a Isenberg, David A.4 aut
7001 a Rahman, Anisur4 aut
7001 a Merrill, Joan T.4 aut
7001 a Alarcon, Graciela S.4 aut
7001 a Fessler, Barri J.4 aut
7001 a Fortin, Paul R.4 aut
7001 a Hanly, John G.4 aut
7001 a Petri, Michelle4 aut
7001 a Steinsson, Kristjan4 aut
7001 a Dooley, Mary-Anne4 aut
7001 a Manzi, Susan4 aut
7001 a Khamashta, Munther A.4 aut
7001 a Ramsey-Goldman, Rosalind4 aut
7001 a Zoma, Asad A.4 aut
7001 a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
7001 a Aranow, Cynthia4 aut
7001 a Mackay, Meggan4 aut
7001 a Ramos-Casals, Manuel4 aut
7001 a van Vollenhoven, Raymond F.u Karolinska Institutet4 aut
7001 a Kalunian, Kenneth C.4 aut
7001 a Ruiz-Irastorza, Guillermo4 aut
7001 a Lim, Sam4 aut
7001 a Kamen, Diane L.4 aut
7001 a Peschken, Christine A.4 aut
7001 a Inanc, Murat4 aut
7001 a Bruce, Ian N.4 aut
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 72:8, s. 1308-1314q 72:8<1308-1314x 1468-2060x 0003-4967
8564 u http://dx.doi.org/10.1136/annrheumdis-2012-202106x freey FULLTEXT
8564 u https://ard.bmj.com/content/72/8/1308.full.pdf
8564 8u https://lup.lub.lu.se/record/3973242
8564 8u https://doi.org/10.1136/annrheumdis-2012-202106
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:127074773

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