Sökning: WFRF:(Bergström L) > (2005-2009) > Increased expressio...
Fältnamn | Indikatorer | Metadata |
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000 | 04411naa a2200661 4500 | |
001 | oai:gup.ub.gu.se/42985 | |
003 | SwePub | |
008 | 240528s2007 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:12539183 | |
024 | 7 | a https://gup.ub.gu.se/publication/429852 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:125391832 URI |
024 | 7 | a https://doi.org/10.4049/jimmunol.178.6.35362 DOI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wagner, C. S.4 aut |
245 | 1 0 | a Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection |
264 | 1 | b The American Association of Immunologists,c 2007 |
520 | a NK and T cells are important for combating CMV infection. Some NK and T cells express leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor recognizing MHC class I and the CMV-encoded homolog UL18. We previously demonstrated an early increase in LIR-1-expressing blood lymphocytes in lung-transplanted patients later developing CMV disease. We now show that NK and T cells account for the observed LIR-1 augmentation. Coincubation of PBMC from CMV-seropositive donors with virus-infected lung fibroblasts led to a T cell-dependent secretion of IFN-gamma, produced mainly by LIR-1(+) T cells and by NK cells. Cytokine production during coculture with fibroblasts infected with virus containing the UL18 gene was augmented compared with the UL18 deletion virus, suggesting a stimulatory role for UL18. However, purified UL18Fc proteins inhibited IFN-gamma production of LIR-1(+) T cells. We propose that cytokine production in the transplant induces NK and T cells to express LIR-1, which may predispose to CMV disease by MHC/LIR-1-mediated suppression. Although the UL18/LIR-1 interaction could inhibit T cell responses, this unlikely plays a role in response to infected cells. Instead, our data point to an activating role for viral UL18 during infection, where indirect intracellular effects cannot be excluded. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Bystander Effect/immunology | |
653 | a Capsid Proteins/biosynthesis/*immunology | |
653 | a Cells | |
653 | a Cultured | |
653 | a Coculture Techniques | |
653 | a Cytomegalovirus/immunology | |
653 | a Cytomegalovirus Infections/etiology/*immunology/metabolism | |
653 | a Female | |
653 | a Fibroblasts/immunology/metabolism/virology | |
653 | a Histocompatibility Antigens Class I/immunology/metabolism | |
653 | a Humans | |
653 | a *Immune Tolerance | |
653 | a Immunity | |
653 | a Cellular | |
653 | a Killer Cells | |
653 | a Natural/immunology/metabolism | |
653 | a Lung Transplantation/*immunology | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Receptors | |
653 | a Immunologic/biosynthesis/*immunology | |
653 | a T-Lymphocytes/*immunology/metabolism | |
700 | 1 | a Riise, Gerdt C.,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xriige |
700 | 1 | a Bergström, Tomas,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xberto |
700 | 1 | a Kärre, K.u Karolinska Institutet4 aut |
700 | 1 | a Carbone, E.u Karolinska Institutet4 aut |
700 | 1 | a Berg, L.u Karolinska Institutet4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin4 org |
773 | 0 | t J Immunold : The American Association of Immunologistsg 178:6, s. 3536-43q 178:6<3536-43x 0022-1767x 1550-6606 |
856 | 4 | u http://www.jimmunol.org/content/178/6/3536.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/42985 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:12539183 |
856 | 4 8 | u https://doi.org/10.4049/jimmunol.178.6.3536 |
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