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Obsessive-compulsiv...
Obsessive-compulsivity and working memory are associated with differential prefrontal cortex and insula activation in adolescents with a recent diagnosis of an eating disorder
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- Brooks, Samantha J (author)
- Uppsala universitet,Funktionell farmakologi
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- Solstrand Dahlberg, Linda (author)
- Uppsala universitet,Funktionell farmakologi
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- Swenne, Ingemar (author)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
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- Aronsson, Marianne (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Zarei, Sanaz (author)
- Uppsala universitet,Funktionell farmakologi
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- Lundberg, Lina (author)
- Uppsala universitet,Funktionell farmakologi
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- Jacobsson, Josefin A (author)
- Uppsala universitet,Funktionell farmakologi
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- Rask-Andersen, Mathias (author)
- Uppsala universitet,Funktionell farmakologi
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- Salonen-Ros, Helena (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- Rosling, Agneta (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Enheten för radiologi
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- Schiöth, Helgi B (author)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Psychiatry Research. - : Elsevier BV. - 0165-1781 .- 1872-7123 .- 0925-4927. ; 224:3, s. 246-253
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The role of rumination at the beginning of eating disorder (ED) is not well understood. We hypothesised that impulsivity, rumination and restriction could be associated with neural activity in response to food stimuli in young individuals with eating disorders (ED). We measured neural responses with functional magnetic resonance imaging (fMRI), tested working memory (WM) and administered the eating disorders examination questionnaire (EDE-Q), Barratt impulsivity scale (BIS-11) and obsessive-compulsive inventory (OCI-R) in 15 adolescent females with eating disorder not otherwise specified (EDNOS) (mean age 15 years) and 20 age-matched healthy control females. We found that EDNOS subjects had significantly higher scores on the BIS 11, EDE-Q and OCI-R scales. Significantly increased neural responses to food images in the EDNOS group were observed in the prefrontal circuitry. OCI-R scores in the EDNOS group also significantly correlated with activity in the prefrontal circuitry and the cerebellum. Significantly slower WM responses negatively correlated with bilateral superior frontal gyrus activity in the EDNOS group. We conclude that ruminations, linked to WM, are present in adolescent females newly diagnosed with EDNOS. These may be risk factors for the development of an eating disorder and may be detectable before disease onset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brooks, Samantha ...
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Solstrand Dahlbe ...
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Swenne, Ingemar
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Aronsson, Marian ...
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Zarei, Sanaz
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Lundberg, Lina
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show more...
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Jacobsson, Josef ...
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Rask-Andersen, M ...
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Salonen-Ros, Hel ...
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Rosling, Agneta
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Larsson, Elna-Ma ...
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Schiöth, Helgi B
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Psychiatry Resea ...
- By the university
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Uppsala University