Sökning: WFRF:(Hesselstrand R.) > Brief Report : IRF4...
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000 | 12499naa a2201417 4500 | |
001 | oai:lup.lub.lu.se:d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8 | |
003 | SwePub | |
008 | 160921s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134219295 | |
024 | 7 | a https://lup.lub.lu.se/record/d5fa7c4f-87c1-4abe-b5d1-84993d4eaac82 URI |
024 | 7 | a https://doi.org/10.1002/art.397302 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1342192952 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a López-Isac, Elenau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
245 | 1 0 | a Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies |
264 | c 2016-08-25 | |
264 | 1 | b Wiley,c 2016 |
300 | a 7 s. | |
520 | a Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a GWAS | |
653 | a Rheumatoid Arthritis | |
653 | a IRF4 | |
653 | a SYSTEMIC SCLEROSIS | |
700 | 1 | a Martín, Jose Ezequielu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Assassi, Shervinu University of Texas4 aut |
700 | 1 | a Simeón, Carmen P.u Vall d'Hebron University Hospital4 aut |
700 | 1 | a Carreira, Patriciau 12 de Octubre University Hospital,University Medical Center Utrecht4 aut |
700 | 1 | a Ortego-Centeno, Norbertou Hospital Clínico Universitario San Cecilio4 aut |
700 | 1 | a Freire, Maykau University of Vigo,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Beltrán, Emmau Valencia University Hospital,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Narváez, Javieru Bellvitge University Hospital-IDIBELL,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Alegre-Sancho, Juan J.u Hospital Universitario Doctor Peset,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Fernández-Gutiérrez, Benjamínu Hospital Clinico San Carlos de Madrid4 aut |
700 | 1 | a Balsa, Alejandrou University Hospital La Paz4 aut |
700 | 1 | a Ortiz, Ana M.u Hospital Universitario de la Princesa4 aut |
700 | 1 | a González-Gay, Miguel A.u University of Cantabria4 aut |
700 | 1 | a Beretta, Lorenzou Maggiore Hospital Policlinico4 aut |
700 | 1 | a Santaniello, Alessandrou Maggiore Hospital Policlinico4 aut |
700 | 1 | a Bellocchi, Chiarau Maggiore Hospital Policlinico4 aut |
700 | 1 | a Lunardi, Claudiou University of Verona4 aut |
700 | 1 | a Moroncini, Gianlucau Marche Polytechnic University4 aut |
700 | 1 | a Gabrielli, Armandou Marche Polytechnic University4 aut |
700 | 1 | a Witte, Torstenu Hannover Medical School4 aut |
700 | 1 | a Hunzelmann, Nicolasu University of Cologne4 aut |
700 | 1 | a Distler, Jörg H Wu Friedrich-Alexander University Erlangen-Nürnberg4 aut |
700 | 1 | a Riekemasten, Gabriellau British Columbia Children's Hospital4 aut |
700 | 1 | a van der Helm-van Mil, Annette H.u Leiden University Medical Centre4 aut |
700 | 1 | a de Vries-Bouwstra, Jeskau Leiden University Medical Centre4 aut |
700 | 1 | a Magro-Checa, Cesaru Leiden University Medical Centre4 aut |
700 | 1 | a Voskuyl, Alexandre E.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Vonk, Madelon C.u Radboud University Nijmegen4 aut |
700 | 1 | a Molberg, Øyvindu University of Oslo4 aut |
700 | 1 | a Merriman, Tonyu University of Otago4 aut |
700 | 1 | a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Forskargruppen för systemisk skleros, Lund,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Lund Systemic Sclerosis Research Group4 aut0 (Swepub:lu)reum-rhe |
700 | 1 | a Nordin, Annikau Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Padyukov, Leonidu Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Herrick, Arianeu University of Manchester4 aut |
700 | 1 | a Eyre, Steveu University of Manchester4 aut |
700 | 1 | a Koeleman, Bobby P Cu University Medical Center Utrecht4 aut |
700 | 1 | a Denton, Christopher P.u University College London4 aut |
700 | 1 | a Fonseca, Carmenu University College London4 aut |
700 | 1 | a Radstake, Timothy R D Ju University Medical Center Utrecht,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Worthington, Janeu University of Manchester4 aut |
700 | 1 | a Mayes, Maureen D.u University of Texas4 aut |
700 | 1 | a Martín, Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Ríos, Raquelu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Callejas, Jose Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Hitos, José Antonio Vargasu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Portales, Rosa Garcíau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Camps, María Teresau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Fernández-Nebro, Antoniou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a González-Escribano, María F.u CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a García-Hernández, Francisco Joséu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Castillo, Ma Jesúsu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Ángeles Aguirre, Mau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Gómez-Gracia, Inmaculadau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Rodríguez-Rodríguez, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Peña, Paloma García de lau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Vicente, Estheru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Andreu, José Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a de Castro, Mónica Fernándezu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a López-Longo, Francisco Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Martínez, Linau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Fonollosa, Vicenteu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Guillén, Alfredou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Castellví, Ivánu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Espinosa, Gerardu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Tolosa, Carlosu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Pros, Annau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Carballeira, Mónica Rodríguezu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Narváez, Francisco Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Rivas, Manel Rubiou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Ortiz-Santamaría, Verau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Madroñero, Ana Belénu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Díaz, Bernardinou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Trapiella, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Sousa, Adriánu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Egurbide, María Victoriau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Mateo, Patricia Fanlou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Sáez-Comet, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Díaz, Federicou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Hernández, Vanesau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Beltrán, Emmau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Román-Ivorra, José Andrésu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Grau, Elenau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Alegre-Sancho, Juan Joséu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Blanco García, Francisco J.u CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
700 | 1 | a Oreiro, Natividadu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut |
710 | 2 | a CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)b University of Texas4 org |
773 | 0 | t Arthritis & Rheumatologyd : Wileyg 68:9, s. 2338-2344q 68:9<2338-2344x 2326-5191x 2326-5205 |
856 | 4 | u http://dx.doi.org/10.1002/art.39730y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39730 |
856 | 4 8 | u https://lup.lub.lu.se/record/d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8 |
856 | 4 8 | u https://doi.org/10.1002/art.39730 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134219295 |
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