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FältnamnIndikatorerMetadata
00008303naa a2200733 4500
001oai:DiVA.org:uu-383842
003SwePub
008190524s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3838422 URI
0247 a https://doi.org/10.2337/DB18-11932 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ma, Jiantaou NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Tufts Univ, Nutr Data Sci, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA4 aut
2451 0a A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
264 1b AMER DIABETES ASSOC,c 2019
338 a print2 rdacarrier
520 a Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding P = 6.9 x 10(-6)) with replication at Bonferroni-corrected P < 8.6 x 10(-4). Mendelian randomization analyses supported the association of hypomethylation of cg08309687 (LINC00649) with NAFLD (P = 2.5 x 10(-4)). Hypomethylation of the same CpG was also associated with risk for new-onset T2D (P = 0.005). Our study demonstrates that a peripheral blood-derived DNA methylation signature is robustly associated with hepatic fat accumulation. The hepatic fat-associated CpGs may represent attractive biomarkers for T2D. Future studies are warranted to explore mechanisms and to examine DNA methylation signatures of NAFLD across racial/ethnic groups.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Nano, Janau Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res, Munich, Germany4 aut
7001 a Ding, Jingzhongu Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA4 aut
7001 a Zheng, Yinanu Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA4 aut
7001 a Hennein, Rachelu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA4 aut
7001 a Liu, Chunyuu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Dept Biostat, Boston, MA 02215 USA4 aut
7001 a Speliotes, Elizabeth K.u Univ Michigan, Sch Med, Ann Arbor, MI USA4 aut
7001 a Huan, Tianxiaou NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA4 aut
7001 a Song, Ciu Uppsala universitet,Molekylär epidemiologi,NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA4 aut0 (Swepub:uu)ciaso492
7001 a Mendelson, Michael M.u NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Harvard Med Sch, Dept Cardiol, Boston Childrens Hosp, Boston, MA 02115 USA4 aut
7001 a Joehanes, Robyu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA4 aut
7001 a Long, Michelle T.u Boston Univ, Sch Med, Dept Med, Gastroenterol Sect, Boston, MA 02118 USA4 aut
7001 a Liang, Limingu Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA4 aut
7001 a Smith, Jennifer A.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Reynolds, Lindsay M.u Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA4 aut
7001 a Ghanbari, Mohsenu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran4 aut
7001 a Muka, Taulantu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands4 aut
7001 a van Meurs, Joyce B. J.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands4 aut
7001 a Alferink, Louise J. M.u Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands4 aut
7001 a Franco, Oscar H.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands4 aut
7001 a Dehghan, Abbasu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Imperial Coll London, Dept Biostat & Epidemiol, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England4 aut
7001 a Ratliff, Scottu Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Zhao, Weiu Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Bielak, Lawrenceu Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Kardia, Sharon L. R.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Peyser, Patricia A.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA4 aut
7001 a Ning, Hongyanu Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA4 aut
7001 a VanWagner, Lisa B.u Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA;Northwestern Univ, Dept Med, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA4 aut
7001 a Lloyd-Jones, Donald M.u Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA4 aut
7001 a Carr, John Jeffreyu Vanderbilt Univ, Med Ctr, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA4 aut
7001 a Greenland, Philipu Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA4 aut
7001 a Lichtenstein, Alice H.u Tufts Univ, USDA, Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, Boston, MA 02111 USA4 aut
7001 a Hu, Frank B.u Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA4 aut
7001 a Liu, Yongmeiu Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA4 aut
7001 a Hou, Lifangu Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA4 aut
7001 a Murad, Sarwa Darwishu Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands4 aut
7001 a Levy, Danielu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA4 aut
7102 a NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Tufts Univ, Nutr Data Sci, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USAb Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res, Munich, Germany4 org
7730 t Diabetesd : AMER DIABETES ASSOCg 68:5, s. 1073-1083q 68:5<1073-1083x 0012-1797x 1939-327X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383842
8564 8u https://doi.org/10.2337/DB18-1193

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