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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003834naa a2200385 4500
001oai:DiVA.org:uu-245093
003SwePub
008150224s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:131955424
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2450932 URI
0247 a https://doi.org/10.1016/j.clnu.2014.09.0202 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1319554242 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Skröder, Helena Mu Karolinska Institutet4 aut
2451 0a Selenium status in pregnancy influences children's cognitive function at 1.5 years of age
264 1b Elsevier BV,c 2015
338 a print2 rdacarrier
520 a BACKGROUND & AIMS: Selenium deficiency has been shown to affect the neurological development in animals, but human research in this area is scarce. We aimed to assess the impact of selenium status during pregnancy on child development at 1.5 years of age.METHODS: This prospective cohort study was nested into a food and micronutrient supplementation trial (MINIMat) conducted in rural Bangladesh. Using inductively coupled plasma mass spectrometry, we measured selenium concentrations in erythrocyte fraction of blood collected from 750 mothers at gestational week 30, and calculated μg per g hemoglobin. A revised version of Bayley Scales of Infant Development was used to assess children's mental and psychomotor development. A Bangladeshi version of MacArthur's Communicative Development Inventory was used to assess language comprehension and expression. Linear regression analyses adjusted for multiple covariates were used to assess the associations.RESULTS: Maternal erythrocyte selenium concentrations varied considerably, from 0.19 to 0.87 μg/g hemoglobin (median 0.46 μg/g hemoglobin), and were associated with developmental measures. An increase in erythrocyte selenium by 0.50 μg/g hemoglobin was associated with an increase in children's language comprehension by 3.7 points (0.5 standard deviations; 95% confidence interval: 0.40, 7.1; p = 0.028). The same increase in erythrocyte selenium corresponded to an increase in the girls' psychomotor development by 12 points (0.9 standard deviation; 95% confidence interval: 4.3, 19; p = 0.002), but much less in boys.CONCLUSIONS: Low prenatal selenium status seems to be disadvantageous for children's psychomotor and language development. Further studies are needed to elucidate the underlying mechanisms of these effects.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
7001 a Hamadani, Jena Du International Center for Diarrheal Disease Research, Dhaka, Bangladesh4 aut
7001 a Tofail, Fahmidau International Center for Diarrheal Disease Research, Dhaka, Bangladesh4 aut
7001 a Persson, Lars-Ake,d 1947-u Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Internationell barnhälsa och nutrition/Persson4 aut0 (Swepub:uu)laper499
7001 a Vahter, Marie Eu Karolinska Institutet4 aut
7001 a Kippler, Maria Ju Karolinska Institutet4 aut
7001 a Persson, TA4 aut
7102 a Karolinska Institutetb International Center for Diarrheal Disease Research, Dhaka, Bangladesh4 org
7730 t Clinical Nutritiond : Elsevier BVg 34:5, s. 923-930q 34:5<923-930x 0261-5614x 1532-1983
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245093
8564 8u https://doi.org/10.1016/j.clnu.2014.09.020
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131955424

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