Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

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Fältnamn	Indikatorer	Metadata
000		07736naa a2201153 4500
001		oai:lup.lub.lu.se:a54b9548-f630-4c17-b90a-b950781ab7c0
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-76247
024	7	a https://lup.lub.lu.se/record/39305962 URI
024	7	a https://doi.org/10.3945/ajcn.112.0521832 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-762472 URI
040		a (SwePub)lud (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Tanaka, Toshiko4 aut
245	1 0	a Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
264	1	b Elsevier BV,c 2013
520		a Background: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake. Design: We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations of European descent. Macronutrients were assessed by using food-frequency questionnaires and analyzed as percentages of total energy consumption from total fat, protein, and carbohydrate. From the discovery GWA (n = 38,360), 35 independent loci associated with macronutrient intake at P < 5 x 10(-6) were identified and taken forward to replication in 3 additional cohorts (n = 33,533) from the DietGen Consortium. For one locus, fat mass obesity-associated protein (FTO), cohorts with Illumina MetaboChip genotype data (n 7724) provided additional replication data. Results: A variant in the chromosome 19 locus (rs838145) was associated with higher carbohydrate (beta +/- SE: 0.25 +/- 0.04%; P = 1.68 x 10(-8)) and lower fat (beta = SE: -0.21 +/- 0.04%; P = 1.57 x 10(-9)) consumption. A candidate gene in this region, fibroblast growth factor 21 (FGF21), encodes a fibroblast growth factor involved in glucose and lipid metabolism. The variants in this locus were associated with circulating FGF21 protein concentrations (P < 0.05) but not mRNA concentrations in blood or brain. The body mass index (BMI) increasing allele of the FTO variant (rs1421085) was associated with higher protein intake (beta +/- SE: 0.10 +/- 0.02%; P = 9.96 x 10(-10)), independent of BMI (after adjustment for BMI, beta +/- SE: 0.08 +/- 0.02%; P = 3.15 x 10(-7)). Conclusion: Our results indicate that variants in genes involved in nutrient metabolism and obesity are associated with macronutrient consumption in humans. Trials related to this study were registered at clinicaltrials.gov as NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetic and Environmental Determinants of Triglycerides), NCT01331512 (InCHIANTI Study), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Ngwa, Julius S.4 aut
700	1	a van Rooij, Frank J. A.4 aut
700	1	a Zillikens, M. Carola4 aut
700	1	a Wojczynski, Mary K.4 aut
700	1	a Frazier-Wood, Alexis C.4 aut
700	1	a Houston, Denise K.4 aut
700	1	a Kanoni, Stavroula4 aut
700	1	a Lemaitre, Rozenn N.4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Mikkila, Vera4 aut
700	1	a Renström, Fridau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
700	1	a Zhao, Jing Hua4 aut
700	1	a Chu, Audrey Y.4 aut
700	1	a Qi, Lu4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Otto, Marcia C. de Oliveira4 aut
700	1	a Dhurandhar, Emily J.4 aut
700	1	a Feitosa, Mary F.4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003
700	1	a Khaw, Kay-Tee4 aut
700	1	a Lohman, Kurt K.4 aut
700	1	a Manichaikul, Ani4 aut
700	1	a McKeown, Nicola M.4 aut
700	1	a Mozaffarian, Dariush4 aut
700	1	a Singleton, Andrew4 aut
700	1	a Stirrups, Kathleen4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Ye, Zheng4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Barroso, Ines4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Forouhi, Nita G.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Lyytikainen, Leo-Pekka4 aut
700	1	a North, Kari E.4 aut
700	1	a Dimitriou, Maria4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001
700	1	a Kahonen, Mika4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Ordovas, Jose M.4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Kalafati, Ioanna-Panagiota4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Johnson, Andrew4 aut
700	1	a Emilsson, Valur4 aut
700	1	a Schrack, Jennifer A.4 aut
700	1	a Semba, Richard D.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Arnett, Donna K.4 aut
700	1	a Borecki, Ingrid B.4 aut
700	1	a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)pafr0003
700	1	a Kritchevsky, Stephen B.4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Loos, Ruth J. F.4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Rotter, Jerome I.4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Dedoussis, George4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a Nettleton, Jennifer A.4 aut
710	2	a Genetisk och molekylär epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t American Journal of Clinical Nutritiond : Elsevier BVg 97:6, s. 1395-1402q 97:6<1395-1402x 1938-3207x 0002-9165
856	4	u http://dx.doi.org/10.3945/ajcn.112.052183x freey FULLTEXT
856	4	u https://academic.oup.com/ajcn/article-pdf/97/6/1395/23819386/1395.pdf
856	4	u http://www.nutrition.org/publications/guidelines-and-policies/license/
856	4 8	u https://lup.lub.lu.se/record/3930596
856	4 8	u https://doi.org/10.3945/ajcn.112.052183
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76247

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Av författaren/redakt...: Tanaka, Toshiko; Ngwa, Julius S.; van Rooij, Frank ...; Zillikens, M. Ca ...; Wojczynski, Mary ...; Frazier-Wood, Al ...; visa fler...; Houston, Denise ...; Kanoni, Stavroul ...; Lemaitre, Rozenn ...; Luan, Jian'an; Mikkila, Vera; Renström, Frida; Sonestedt, Emily; Zhao, Jing Hua; Chu, Audrey Y.; Qi, Lu; Chasman, Daniel ...; Otto, Marcia C. ...; Dhurandhar, Emil ...; Feitosa, Mary F.; Johansson, Ingeg ...; Khaw, Kay-Tee; Lohman, Kurt K.; Manichaikul, Ani; McKeown, Nicola ...; Mozaffarian, Dar ...; Singleton, Andre ...; Stirrups, Kathle ...; Viikari, Jorma; Ye, Zheng; Bandinelli, Stef ...; Barroso, Ines; Deloukas, Panos; Forouhi, Nita G.; Hofman, Albert; Liu, Yongmei; Lyytikainen, Leo ...; North, Kari E.; Dimitriou, Maria; Hallmans, Göran; Kahonen, Mika; Langenberg, Clau ...; Ordovas, Jose M.; Uitterlinden, An ...; Hu, Frank B.; Kalafati, Ioanna ...; Raitakari, Olli; Franco, Oscar H.; Johnson, Andrew; Emilsson, Valur; Schrack, Jennife ...; Semba, Richard D ...; Siscovick, David ...; Arnett, Donna K.; Borecki, Ingrid ...; Franks, Paul; Kritchevsky, Ste ...; Lehtimaki, Terho; Loos, Ruth J. F.; Orho-Melander, M ...; Rotter, Jerome I ...; Wareham, Nichola ...; Witteman, Jacque ...; Ferrucci, Luigi; Dedoussis, Georg ...; Cupples, L. Adri ...; Nettleton, Jenni ...; visa färre...

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