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Validation of Clinical COPD Phenotypes for Prognosis of Long-Term Mortality in Swedish and Dutch Cohorts

Gagatek, Sebastian (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Wijnant, S. R. A. (författare)
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium,Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Ghent, Fac Pharmaceut Sci, Dept Bioanal, Ghent, Belgium.
Ställberg, Björn, Docent (författare)
Uppsala universitet,Allmänmedicin och preventivmedicin
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Lisspers, Karin, Docent, 1954- (författare)
Uppsala universitet,Allmänmedicin och preventivmedicin
Brusselle, G. (författare)
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherland; Department of Respiratory Medicine, Erasmus Medical Centre, Rotterdam, Netherlands,Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Resp Med, Rotterdam, Netherlands.
Zhou, Xingwu (författare)
Uppsala universitet,Lung- allergi- och sömnforskning,Klinisk fysiologi
Hasselgren, Mikael, 1964- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
Montgomery, Scott, 1961- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics,Örebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Örebro, Sweden.
Sundh, Josefin, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Respiratory Medicine,Örebro Univ, Fac Med & Hlth, Dept Resp Med, Örebro, Sweden.
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Emilsson, Össur Ingi (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Lahousse, L. (författare)
Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Ghent, Fac Pharmaceut Sci, Dept Bioanal, Ghent, Belgium.
Malinovschi, Andrei, 1978- (författare)
Uppsala universitet,Klinisk fysiologi
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 (creator_code:org_t)
2022-09-08
2022
Engelska.
Ingår i: COPD. - : Informa Healthcare. - 1541-2555 .- 1541-2563. ; 19:1, s. 330-338
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with variable mortality risk. The aim of our investigation was to validate a simple clinical algorithm for long-term mortality previously proposed by Burgel et al. in 2017. Subjects with COPD from two cohorts, the Swedish PRAXIS study (n = 784, mean age (standard deviation (SD)) 64.0 years (7.5), 42% males) and the Rotterdam Study (n = 735, mean age (SD) 72 years (9.2), 57% males), were included. Five clinical clusters were derived from baseline data on age, body mass index, dyspnoea grade, pulmonary function and comorbidity (cardiovascular disease/diabetes). Cox models were used to study associations with 9-year mortality. The distribution of clinical clusters (1-5) was 29%/45%/8%/6%/12% in the PRAXIS study and 23%/26%/36%/0%/15% in the Rotterdam Study. The cumulative proportion of deaths at the 9-year follow-up was highest in clusters 1 (65%) and 4 (72%), and lowest in cluster 5 (10%) in the PRAXIS study. In the Rotterdam Study, cluster 1 (44%) had the highest cumulative mortality and cluster 5 (5%) the lowest. Compared with cluster 5, the meta-analysed age- and sex-adjusted hazard ratio (95% confidence interval) for cluster 1 was 6.37 (3.94-10.32) and those for clusters 2 and 3 were 2.61 (1.58-4.32) and 3.06 (1.82-5.13), respectively. Burgel's clinical clusters can be used to predict long-term mortality risk. Clusters 1 and 4 are associated with the poorest prognosis, cluster 5 with the best prognosis and clusters 2 and 3 with intermediate prognosis in two independent cohorts from Sweden and the Netherlands.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

COPD
comorbidities
epidemiology
mortality
phenotypes

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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