Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Mullins S) > Chronic neuropsychi...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		09650naa a2201417 4500
001		oai:gup.ub.gu.se/322192
003		SwePub
008		240528s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3221922 URI
024	7	a https://doi.org/10.1002/trc2.123482 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a de Erausquin, Gabriel A4 aut
245	1 0	a Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.
264		c 2022-09-22
264	1	b Wiley,c 2022
520		a Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term.This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions.Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe.The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection.The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Snyder, Heather4 aut
700	1	a Brugha, Traolach S4 aut
700	1	a Seshadri, Sudha4 aut
700	1	a Carrillo, Maria4 aut
700	1	a Sagar, Rajesh4 aut
700	1	a Huang, Yueqin4 aut
700	1	a Newton, Charles4 aut
700	1	a Tartaglia, Carmela4 aut
700	1	a Teunissen, Charlotte4 aut
700	1	a Håkanson, Krister4 aut
700	1	a Akinyemi, Rufus4 aut
700	1	a Prasad, Kameshwar4 aut
700	1	a D'Avossa, Giovanni4 aut
700	1	a Gonzalez-Aleman, Gabriela4 aut
700	1	a Hosseini, Akram4 aut
700	1	a Vavougios, George D4 aut
700	1	a Sachdev, Perminder4 aut
700	1	a Bankart, John4 aut
700	1	a Mors, Niels Peter Ole4 aut
700	1	a Lipton, Richard4 aut
700	1	a Katz, Mindy4 aut
700	1	a Fox, Peter T4 aut
700	1	a Katshu, Mohammad Zia4 aut
700	1	a Iyengar, M Sriram4 aut
700	1	a Weinstein, Galit4 aut
700	1	a Sohrabi, Hamid R4 aut
700	1	a Jenkins, Rachel4 aut
700	1	a Stein, Dan J4 aut
700	1	a Hugon, Jacques4 aut
700	1	a Mavreas, Venetsanos4 aut
700	1	a Blangero, John4 aut
700	1	a Cruchaga, Carlos4 aut
700	1	a Krishna, Murali4 aut
700	1	a Wadoo, Ovais4 aut
700	1	a Becerra, Rodrigo4 aut
700	1	a Zwir, Igor4 aut
700	1	a Longstreth, William T4 aut
700	1	a Kroenenberg, Golo4 aut
700	1	a Edison, Paul4 aut
700	1	a Mukaetova-Ladinska, Elizabeta4 aut
700	1	a Staufenberg, Ekkehart4 aut
700	1	a Figueredo-Aguiar, Mariana4 aut
700	1	a Yécora, Agustín4 aut
700	1	a Vaca, Fabiana4 aut
700	1	a Zamponi, Hernan P4 aut
700	1	a Re, Vincenzina Lo4 aut
700	1	a Majid, Abdul4 aut
700	1	a Sundarakumar, Jonas4 aut
700	1	a Gonzalez, Hector M4 aut
700	1	a Geerlings, Mirjam I4 aut
700	1	a Skoog, Ingmar,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)4 aut0 (Swepub:gu)xskooi
700	1	a Salmoiraghi, Alberto4 aut
700	1	a Boneschi, Filippo Martinelli4 aut
700	1	a Patel, Vibuthi N4 aut
700	1	a Santos, Juan M4 aut
700	1	a Arroyo, Guillermo Rivera4 aut
700	1	a Moreno, Antonio Caballero4 aut
700	1	a Felix, Pascal4 aut
700	1	a Gallo, Carla4 aut
700	1	a Arai, Hidenori4 aut
700	1	a Yamada, Masahito4 aut
700	1	a Iwatsubo, Takeshi4 aut
700	1	a Sharma, Malveeka4 aut
700	1	a Chakraborty, Nandini4 aut
700	1	a Ferreccio, Catterina4 aut
700	1	a Akena, Dickens4 aut
700	1	a Brayne, Carol4 aut
700	1	a Maestre, Gladys4 aut
700	1	a Blangero, Sarah Williams4 aut
700	1	a Brusco, Luis I4 aut
700	1	a Siddarth, Prabha4 aut
700	1	a Hughes, Timothy M4 aut
700	1	a Zuñiga, Alfredo Ramírez4 aut
700	1	a Kambeitz, Joseph4 aut
700	1	a Laza, Agustin Ruiz4 aut
700	1	a Allen, Norrina4 aut
700	1	a Panos, Stella4 aut
700	1	a Merrill, David4 aut
700	1	a Ibáñez, Agustín4 aut
700	1	a Tsuang, Debby4 aut
700	1	a Valishvili, Nino4 aut
700	1	a Shrestha, Srishti4 aut
700	1	a Wang, Sophia4 aut
700	1	a Padma, Vasantha4 aut
700	1	a Anstey, Kaarin J4 aut
700	1	a Ravindrdanath, Vijayalakshmi4 aut
700	1	a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
700	1	a Mullins, Paul4 aut
700	1	a Łojek, Emilia4 aut
700	1	a Pria, Anand4 aut
700	1	a Mosley, Thomas H4 aut
700	1	a Gowland, Penny4 aut
700	1	a Girard, Timothy D4 aut
700	1	a Bowtell, Richard4 aut
700	1	a Vahidy, Farhaan S4 aut
710	2	a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Alzheimer's & dementia (New York, N. Y.)d : Wileyg 8:1q 8:1x 2352-8737
856	4 8	u https://gup.ub.gu.se/publication/322192
856	4 8	u https://doi.org/10.1002/trc2.12348

Hitta via bibliotek

Alzheimer's & dementia (New York, N. Y.) (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: de Erausquin, Ga ...; Snyder, Heather; Brugha, Traolach ...; Seshadri, Sudha; Carrillo, Maria; Sagar, Rajesh; visa fler...; Huang, Yueqin; Newton, Charles; Tartaglia, Carme ...; Teunissen, Charl ...; Håkanson, Kriste ...; Akinyemi, Rufus; Prasad, Kameshwa ...; D'Avossa, Giovan ...; Gonzalez-Aleman, ...; Hosseini, Akram; Vavougios, Georg ...; Sachdev, Permind ...; Bankart, John; Mors, Niels Pete ...; Lipton, Richard; Katz, Mindy; Fox, Peter T; Katshu, Mohammad ...; Iyengar, M Srira ...; Weinstein, Galit; Sohrabi, Hamid R; Jenkins, Rachel; Stein, Dan J; Hugon, Jacques; Mavreas, Venetsa ...; Blangero, John; Cruchaga, Carlos; Krishna, Murali; Wadoo, Ovais; Becerra, Rodrigo; Zwir, Igor; Longstreth, Will ...; Kroenenberg, Gol ...; Edison, Paul; Mukaetova-Ladins ...; Staufenberg, Ekk ...; Figueredo-Aguiar ...; Yécora, Agustín; Vaca, Fabiana; Zamponi, Hernan ...; Re, Vincenzina L ...; Majid, Abdul; Sundarakumar, Jo ...; Gonzalez, Hector ...; Geerlings, Mirja ...; Skoog, Ingmar, 1 ...; Salmoiraghi, Alb ...; Boneschi, Filipp ...; Patel, Vibuthi N; Santos, Juan M; Arroyo, Guillerm ...; Moreno, Antonio ...; Felix, Pascal; Gallo, Carla; Arai, Hidenori; Yamada, Masahito; Iwatsubo, Takesh ...; Sharma, Malveeka; Chakraborty, Nan ...; Ferreccio, Catte ...; Akena, Dickens; Brayne, Carol; Maestre, Gladys; Blangero, Sarah ...; Brusco, Luis I; Siddarth, Prabha; Hughes, Timothy ...; Zuñiga, Alfredo ...; Kambeitz, Joseph; Laza, Agustin Ru ...; Allen, Norrina; Panos, Stella; Merrill, David; Ibáñez, Agustín; Tsuang, Debby; Valishvili, Nino; Shrestha, Srisht ...; Wang, Sophia; Padma, Vasantha; Anstey, Kaarin J; Ravindrdanath, V ...; Blennow, Kaj, 19 ...; Mullins, Paul; Łojek, Emilia; Pria, Anand; Mosley, Thomas H; Gowland, Penny; Girard, Timothy ...; Bowtell, Richard; Vahidy, Farhaan ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Alzheimer's & de ...

Av lärosätet: Göteborgs universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se