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WFRF:(Vollset Stein E)
 

Sökning: WFRF:(Vollset Stein E) > Vitamins B2 and B6 ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005428naa a2200889 4500
001oai:DiVA.org:umu-31570
003SwePub
008100211s2010 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:73f48b94-a303-4b6b-9bf6-65051fe367c7
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-315702 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-08-10962 DOI
0247 a https://lup.lub.lu.se/record/15475532 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
2451 0a Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
264 1c 2010
338 a print2 rdacarrier
520 a B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with GC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Vollset, Stein Emil4 aut
7001 a Hustad, Steinar4 aut
7001 a Midttun, Øivind4 aut
7001 a Meyer, Klaus4 aut
7001 a Fredriksen, Ase4 aut
7001 a Ueland, Per Magne4 aut
7001 a Jenab, Mazda4 aut
7001 a Slimani, Nadia4 aut
7001 a Ferrari, Pietro4 aut
7001 a Agudo, Antonio4 aut
7001 a Sala, Núria4 aut
7001 a Capellá, Gabriel4 aut
7001 a Del Giudice, Giuseppe4 aut
7001 a Palli, Domenico4 aut
7001 a Boeing, Heiner4 aut
7001 a Weikert, Cornelia4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a Büchner, Frederike L4 aut
7001 a Carneiro, Fátima4 aut
7001 a Berrino, Franco4 aut
7001 a Vineis, Paolo4 aut
7001 a Tumino, Rosario4 aut
7001 a Panico, Salvatore4 aut
7001 a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe
7001 a Manjer, Jonas4 aut
7001 a Stenling, Rogeru Umeå universitet,Patologi4 aut0 (Swepub:umu)rost0001
7001 a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Martínez, Carmen4 aut
7001 a Arrizola, Larraitz4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Navarro, Carmen4 aut
7001 a Rodriguez, Laudina4 aut
7001 a Bingham, Sheila4 aut
7001 a Linseisen, Jakob4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Overvad, Kim4 aut
7001 a Tjønneland, Anne4 aut
7001 a Peeters, Petra H M4 aut
7001 a Numans, Mattijs E4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Morois, Sophie4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lund, Eiliv4 aut
7001 a Plebani, Mario4 aut
7001 a Riboli, Elio4 aut
7001 a González, Carlos A4 aut
7102 a Kirurgib Forskargrupper vid Lunds universitet4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiong 19:1, s. 28-38q 19:1<28-38x 1055-9965x 1538-7755
8564 u http://dx.doi.org/10.1158/1055-9965.EPI-08-1096y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31570
8564 8u https://doi.org/10.1158/1055-9965.EPI-08-1096
8564 8u https://lup.lub.lu.se/record/1547553

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