In vivo investigation of ECRB tendons with microdialysis technique--no signs of inflammation but high amounts of glutamate in tennis elbow.

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Fältnamn	Indikatorer	Metadata
000		02911naa a2200397 4500
001		oai:DiVA.org:umu-32843
003		SwePub
008		100329s2000 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:1937053
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-328432 URI
024	7	a https://doi.org/10.1080/0001647003173811622 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:19370532 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Alfredson, Håkanu Umeå universitet,Idrottsmedicin4 aut0 (Swepub:umu)haal0002
245	1 0	a In vivo investigation of ECRB tendons with microdialysis technique--no signs of inflammation but high amounts of glutamate in tennis elbow.
264		c 2009-07-08
264	1	b Medical Journals Sweden AB,c 2000
338		a print2 rdacarrier
520		a We used the microdialysis technique to study concentrations of substances in the extensor carpi radialis brevis (ECRB) tendon in patients with tennis elbow. In 4 patients (mean age 41 years, 3 men) with a long duration of localized pain at the ECRB muscle origin, and in 4 controls (mean age 36 years, 2 men) with no history of elbow pain, a standard microdialysis catheter was inserted into the ECRB tendon under local anesthesia. The local concentrations of the neurotransmitter glutamate and prostaglandin E2 (PGE2) were recorded under resting conditions. Samplings were done every 15 minutes during a 2-hour period. We found higher mean concentrations of glutamate in ECRB tendons from patients with tennis elbow than in tendons from controls (215 vs. 69 micromoL/L, p < 0.001). There were no significant differences in the mean concentrations of PGE2 (74 vs. 86 pg/mL). In conclusion, in situ microdialysis can be used to study certain metabolic events in the ECRB tendon of the elbow. Our findings indicate involvement of the excitatory neurotransmitter glutamate, but no biochemical signs of inflammation (normal PGE2 levels) in ECRB tendons from patients with tennis elbow.
653		a MEDICINE
653		a MEDICIN
653		a Medicine
653		a medicin
700	1	a Ljung, B O4 aut
700	1	a Thorsen, Kimu Umeå universitet,Idrottsmedicin4 aut
700	1	a Lorentzon, Ronnyu Umeå universitet,Idrottsmedicin4 aut0 (Swepub:umu)rolo0001
710	2	a Umeå universitetb Idrottsmedicin4 org
773	0	t Acta Orthopaedica Scandinavicad : Medical Journals Sweden ABg 71:5, s. 475-479q 71:5<475-479x 0001-6470
856	4	u https://www.tandfonline.com/doi/pdf/10.1080/000164700317381162?needAccess=true
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32843
856	4 8	u https://doi.org/10.1080/000164700317381162
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:1937053

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Av författaren/redakt...: Alfredson, Håkan; Ljung, B O; Thorsen, Kim; Lorentzon, Ronny

Artiklar i publikationen: Acta Orthopaedic ...

Av lärosätet: Umeå universitet; Karolinska Institutet

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