Synthesis of (-)-pregaliellalactone, conversion of (-)-pregaliellalactone to (-)-galiellalactone by mycelia of Galiella rufa

• An enantioselective synthesis of (-)-pregaliellalactone (1), a biosynthetic precursor of the potent fungal metabolite ( -)-galiellalactone (3) produced by several ascomycetes, is reported. When fed to a culture of Galiella rufa, 1 was efficiently converted to 3. (C) 2002 Elsevier Science Ltd. All rights reserved.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

pregaliellalactone

stannylation

Diels-Alder cyclisation

Galiella rufa

galiellalactone

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)