L773:2157 846X
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04069naa a2200757 4500 | |
| 001 | oai:DiVA.org:kth-267922 | |
| 003 | SwePub | |
| 008 | 200322s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:142846356 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2679222 URI |
| 024 | 7 | a https://doi.org/10.1038/s41551-019-0498-92 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428463562 URI |
| 040 | a (SwePub)kthd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Herland, Annau Karolinska Institutet,KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)u1koqi31 |
| 245 | 1 0 | a Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips |
| 264 | c 2020-01-27 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20200322 | |
| 520 | a Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiological PK modelling of first-pass drug absorption, metabolism and excretion in humans—using computationally scaled data from multiple fluidically linked two-channel organ chips—predicts PK parameters for orally administered nicotine (using gut, liver and kidney chips) and for intravenously injected cisplatin (using coupled bone marrow, liver and kidney chips). The chips are linked through sequential robotic liquid transfers of a common blood substitute by their endothelium-lined channels (as reported by Novak et al. in an associated Article) and share an arteriovenous fluid-mixing reservoir. We also show that predictions of cisplatin PDs match previously reported patient data. The quantitative in-vitro-to-in-vivo translation of PK and PD parameters and the prediction of drug absorption, distribution, metabolism, excretion and toxicity through fluidically coupled organ chips may improve the design of drug-administration regimens for phase-I clinical trials. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng |
| 653 | a Forecasting | |
| 653 | a Hospital data processing | |
| 653 | a Metabolism | |
| 653 | a Pharmacokinetics | |
| 653 | a Clinical trial | |
| 653 | a Drug absorption | |
| 653 | a Drug administration | |
| 653 | a Human pharmacokinetics | |
| 653 | a Liquid transfers | |
| 653 | a Patient data | |
| 653 | a PD parameters | |
| 653 | a Quantitative prediction | |
| 653 | a Physiological models | |
| 700 | 1 | a Maoz, B. M.4 aut |
| 700 | 1 | a Das, D.4 aut |
| 700 | 1 | a Somayaji, M. R.4 aut |
| 700 | 1 | a Prantil-Baun, R.4 aut |
| 700 | 1 | a Novak, R.4 aut |
| 700 | 1 | a Cronce, M.4 aut |
| 700 | 1 | a Huffstater, T.4 aut |
| 700 | 1 | a Jeanty, S. S. F.4 aut |
| 700 | 1 | a Ingram, M.4 aut |
| 700 | 1 | a Chalkiadaki, A.4 aut |
| 700 | 1 | a Benson Chou, D.4 aut |
| 700 | 1 | a Marquez, S.4 aut |
| 700 | 1 | a Delahanty, A.4 aut |
| 700 | 1 | a Jalili-Firoozinezhad, S.4 aut |
| 700 | 1 | a Milton, Y.4 aut |
| 700 | 1 | a Sontheimer-Phelps, A.4 aut |
| 700 | 1 | a Swenor, B.4 aut |
| 700 | 1 | a Levy, O.4 aut |
| 700 | 1 | a Parker, K. K.4 aut |
| 700 | 1 | a Przekwas, A.4 aut |
| 700 | 1 | a Ingber, Donaldu KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)PI000000 |
| 710 | 2 | a KTHb Mikro- och nanosystemteknik4 org |
| 773 | 0 | t Nature Biomedical Engineeringd : Springer Science and Business Media LLCg 4:4, s. 421-436q 4:4<421-436x 2157-846X |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011576 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-267922 |
| 856 | 4 8 | u https://doi.org/10.1038/s41551-019-0498-9 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142846356 |
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