SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Aigner Clemens)
 

Search: WFRF:(Aigner Clemens) > PSD3 downregulation...

  • Mancina, Rosellina MargheritaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

PSD3 downregulation confers protection against fatty liver disease.

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-31
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/313448
  • https://gup.ub.gu.se/publication/313448URI
  • https://doi.org/10.1038/s42255-021-00518-0DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sasidharan, KavithaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsaska (author)
  • Lindblom, Anna (author)
  • Wei, Ying (author)
  • Ciociola, EsterGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcioce (author)
  • Oveis, JamialahmadiGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)
  • Pingitore, Piero,1986Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xpinpi (author)
  • Andréasson, Anne-Christine (author)
  • Pellegrini, Giovanni (author)
  • Baselli, Guido (author)
  • Männistö, Ville (author)
  • Pihlajamäki, Jussi (author)
  • Kärjä, Vesa (author)
  • Grimaudo, Stefania (author)
  • Marini, Ilaria (author)
  • Maggioni, Marco (author)
  • Becattini, BarbaraGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbecba (author)
  • Tavaglione, FedericaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtavfe (author)
  • Dix, Carly (author)
  • Castaldo, Marie (author)
  • Klein, Stephanie (author)
  • Perelis, Mark (author)
  • Pattou, Francois (author)
  • Thuillier, Dorothée (author)
  • Raverdy, Violeta (author)
  • Dongiovanni, Paola (author)
  • Fracanzani, Anna Ludovica (author)
  • Stickel, Felix (author)
  • Hampe, Jochen (author)
  • Buch, Stephan (author)
  • Luukkonen, Panu K (author)
  • Prati, Daniele (author)
  • Yki-Järvinen, Hannele (author)
  • Petta, Salvatore (author)
  • Xing, Chao (author)
  • Schafmayer, Clemens (author)
  • Aigner, Elmar (author)
  • Datz, Christian (author)
  • Lee, Richard G (author)
  • Valenti, Luca (author)
  • Lindén, Daniel (author)
  • Romeo, Stefano,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xroste (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:Nature metabolism: Springer Science and Business Media LLC4:1, s. 60-752522-5812

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view