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Substrate Source Us...
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Boon, Hanneke,1981-Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands & Department of Human Biology, Maastricht University, Maastricht, Netherlands
(författare)
Substrate Source Use in Older, Trained Males after Decades of Endurance Training
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Philadelphia, PA :Lippincott Williams & Wilkins,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:hh-26612
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https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-26612URI
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https://doi.org/10.1249/mss.0b013e3181572aceDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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PURPOSE: The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls. METHODS: [U-C]palmitate and [6,6-H2]glucose tracers were applied to assess plasma free fatty acid (FFA) and glucose oxidation rates, and to estimate muscle- and/or lipoprotein-derived triacylglycerol (TG) and muscle glycogen use. Subjects were 10 long-term exercising, endurance-trained males and 10 sedentary controls (age 57 +/- 1 and 60 +/- 2 yr, respectively). Muscle biopsy samples were collected before and after exercise to assess muscle fiber type-specific intramyocellular lipid and glycogen content. RESULTS: During exercise, plasma palmitate Ra, Rd, and Rox were significantly greater in the trained subjects compared with the controls (Ra: 0.36 +/- 0.02 and 0.25 +/- 0.02; Rd: 0.36 +/- 0.03 and 0.24 +/- 0.02; Rox: 0.31 +/- 0.02 and 0.20 +/- 0.02 mmol.min, respectively, P < 0.01). This resulted in greater plasma FFA and total fat oxidation rates in the trained versus sedentary subjects (P < 0.001). Muscle- and/or lipoprotein-derived TG use contributed 10 +/- 2 and 11 +/- 3% in the trained and control groups, respectively (NS). No significant net changes in muscle fiber lipid content were observed. CONCLUSIONS: Older, endurance-trained males oxidize more fat during moderate-intensity exercise than do sedentary controls. This greater total fat oxidation rate is attributed to a higher plasma FFA release, uptake, and oxidation rate. In contrast, intramyocellular triacylglycerol does not seem to represent a major substrate source during 1 h of moderate-intensity exercise in older trained or sedentary men. ©2007 The American College of Sports Medicine.
Ämnesord och genrebeteckningar
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stable isotopes
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metabolism
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endurance training status
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aging
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intramyocellular triacylglycerol
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glycogen
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jonkers, Richard A. M.Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(författare)
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Koopman, ReneDepartment of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(författare)
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Blaak, Ellen E.Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(författare)
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Saris, Wim H. M.Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(författare)
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Wagenmakers, Anton J. M.School of Sport and Exercise Science, University of Birmingham, Birmingham, United Kingdom
(författare)
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van Loon, Luc J. C.Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands & Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(författare)
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Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands & Department of Human Biology, Maastricht University, Maastricht, NetherlandsDepartment of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Medicine & Science in Sports & ExercisePhiladelphia, PA : Lippincott Williams & Wilkins39:12, s. 2160-21700195-91311530-0315
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