WFRF:(Bonasera A)
Sökning: WFRF:(Bonasera A) > PET with [11C]-Meto...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04183naa a2200385 4500 | |
| 001 | oai:DiVA.org:uu-73654 | |
| 003 | SwePub | |
| 008 | 050613s1999 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-736542 URI |
| 024 | 7 | a https://doi.org/10.1016/S1095-0397(99)00099-02 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bergström, Matsu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala University Pet-Centre4 aut0 (Swepub:uu)matsberg |
| 245 | 1 0 | a PET with [11C]-Metomidate for the Visualization of Adrenocortical Tumors and Discrimination from Other Lesions |
| 264 | 1 | c 1999 |
| 338 | a print2 rdacarrier | |
| 520 | a Purpose:The purpose of the study was to evaluate the potential role of PET with the adrenocortical-specific tracer 11C-metomidate in the characterization of incidentally found adrenal cortical lesions and in adrenocortical carcinomas.Methods:PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT (incidentalomas) and in 9 additional patients with adrenocortical cancer. All incidentalomas subsequently underwent surgery, except 2 subjected to biopsy only. These lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2) and nodular hyperplasia (n = 1). The remaining were non-cortical lesions including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases.Results:All lesions, except 1, with an adrenocortical origin were easily identified due to exceedingly high uptake of 11C-metomidate, whereas the non-cortical lesions showed very low uptake. The 1 false negative was a cancer that at surgery was found to be extensively necrotic. High uptake was also seen in normal adrenal glands. The tracer uptake kinetics indicated trapping of the tracer in the cortical lesions. For quantitative evaluation of tracer binding in individual lesions, the simple SUV concept was found to be equally accurate as more elaborate kinetic analyses.Conclusion:The patients presented and altogether over 40 PET investigations have demonstrated 11C-metomidate to be an attractive tracer for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from non-cortical lesions. Additionally the method allows the assessment of metastases from adrenocortical cancers, and the very high contrast has allowed partial whole-body examinations. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 700 | 1 | a Sörensen, Jensu Uppsala universitet,Enheten för nuklearmedicin och PET,Uppsala University Pet-Centre4 aut0 (Swepub:uu)jenssore |
| 700 | 1 | a Khan, Tanweera Shaheenau Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University Pet-Centre4 aut0 (Swepub:uu)tanwkhan |
| 700 | 1 | a Juhlin, Claesu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala University Pet-Centre4 aut0 (Swepub:uu)claesjl |
| 700 | 1 | a Eriksson, Barbrou Uppsala universitet,Endokrin tumörbiologi4 aut0 (Swepub:uu)barberik |
| 700 | 1 | a Sundin, Andersu Uppsala universitet,Enheten för radiologi,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)anderssu |
| 700 | 1 | a Bonasera, T.A.4 aut |
| 700 | 1 | a Fasth, K.-J.4 aut |
| 700 | 1 | a Långström, Bengtu Uppsala universitet,Enheten för nuklearmedicin och PET,Uppsala University Pet-Centre4 aut0 (Swepub:uu)benglang |
| 710 | 2 | a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org |
| 773 | 0 | t Clinical Positron Imagingg 2:6, s. 339-q 2:6<339-x 1095-0397x 1878-5751 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=14516636&dopt=Citation |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73654 |
| 856 | 4 8 | u https://doi.org/10.1016/S1095-0397(99)00099-0 |
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