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Novel microRNA regu...
Novel microRNA regulators of atrial natriuretic peptide production
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- Wu, Connie (författare)
- Broad Institute,Harvard University,Massachusetts General Hospital
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- Arora, Pankaj (författare)
- University of Alabama
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- Agha, Obiajulu (författare)
- Harvard University,Massachusetts General Hospital
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- Hurst, Liam A. (författare)
- Harvard University,Massachusetts General Hospital
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- Allen, Kaitlin (författare)
- Massachusetts General Hospital,Harvard University
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- Nathan, Daniel I. (författare)
- Harvard University,Massachusetts General Hospital
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- Hu, Dongjian (författare)
- Massachusetts General Hospital,Boston University,Harvard University
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- Jiramongkolchai, Pawina (författare)
- Massachusetts General Hospital,Harvard University
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- Smith, Gustav (författare)
- Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Harvard University,Broad Institute,Massachusetts General Hospital
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Trenson, Sander (författare)
- Catholic University of Leuven
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- Janssens, Stefan P. (författare)
- Catholic University of Leuven
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- Domian, Ibrahim (författare)
- Harvard University,Massachusetts General Hospital
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- Wang, Thomas J (författare)
- Vanderbilt University
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- Bloch, Kenneth D. (författare)
- Massachusetts General Hospital,Harvard University
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- Buys, Emmanuel S. (författare)
- Harvard University,Massachusetts General Hospital
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- Bloch, Donald B. (författare)
- Massachusetts General Hospital,Harvard University
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- Newton-Cheh, Christopher (författare)
- Massachusetts General Hospital,Harvard University,Broad Institute
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(creator_code:org_t)
- 2016
- 2016
- Engelska 11 s.
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Ingår i: Molecular and Cellular Biology. - 0270-7306. ; 36:14, s. 1977-1987
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contain multiple predicted microRNA (miRNA)-binding sites, and binding of different miRNAs may independently or coordinately regulate the expression of any given mRNA. We used a multifaceted screening strategy that integrates bioinformatics, next-generation sequencing data, human genetic association data, and cellular models to identify additional functional NPPA-targeting miRNAs. Two novel miRNAs, miR-155 and miR-105, were found to modulate ANP production in human cardiomyocytes and target genetic variants whose minor alleles are associated with higher human plasma ANP levels. Both miR-155 and miR-105 repressed NPPA mRNA in an allele-specific manner, with the minor allele of each respective variant conferring resistance to the miRNA either by disruption of miRNA base pairing or by creation of wobble base pairing. Moreover, miR-155 enhanced the repressive effects of miR-425 on ANP production in human cardiomyocytes. Our study combines computational, genomic, and cellular tools to identify novel miRNA regulators of ANP production that could be targeted to raise ANP levels, which may have applications for the treatment of hypertension or heart failure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wu, Connie
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Arora, Pankaj
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Agha, Obiajulu
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Hurst, Liam A.
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Allen, Kaitlin
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Nathan, Daniel I ...
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visa fler...
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Hu, Dongjian
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Jiramongkolchai, ...
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Smith, Gustav
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Melander, Olle
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Trenson, Sander
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Janssens, Stefan ...
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Domian, Ibrahim
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Wang, Thomas J
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Bloch, Kenneth D ...
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Buys, Emmanuel S ...
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Bloch, Donald B.
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Newton-Cheh, Chr ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Molecular and Ce ...
- Av lärosätet
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Lunds universitet