Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.

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Fältnamn	Indikatorer	Metadata
000		03409naa a2200613 4500
001		oai:DiVA.org:umu-16702
003		SwePub
008		071009s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167022 URI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hemann, Michael T4 aut
245	1 0	a Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
264	1	c 2005
338		a print2 rdacarrier
520		a The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis.
653		a Adoptive Transfer
653		a Alleles
653		a Animals
653		a Apoptosis
653		a Apoptosis Regulatory Proteins
653		a Burkitt Lymphoma/genetics/metabolism/pathology
653		a Carrier Proteins/metabolism
653		a Cell Cycle Proteins/metabolism
653		a Cell Proliferation
653		a Cyclin-Dependent Kinase Inhibitor p16
653		a Cyclin-Dependent Kinase Inhibitor p21
653		a Genes; myc/*genetics
653		a Humans
653		a Membrane Proteins/metabolism
653		a Mice
653		a Mice; Inbred C57BL
653		a Mutation/*genetics
653		a Proto-Oncogene Proteins/metabolism
653		a Proto-Oncogene Proteins c-bcl-2/metabolism
653		a Proto-Oncogene Proteins c-myc/genetics/metabolism
653		a Stem Cell Transplantation
653		a Tumor Suppressor Protein p14ARF/metabolism
653		a Tumor Suppressor Protein p53/*metabolism
700	1	a Bric, Anka4 aut
700	1	a Teruya-Feldstein, Julie4 aut
700	1	a Herbst, Andreas4 aut
700	1	a Nilsson, Jonas Au Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Nilsson4 aut
700	1	a Cordon-Cardo, Carlos4 aut
700	1	a Cleveland, John L4 aut
700	1	a Tansey, William P4 aut
700	1	a Lowe, Scott W4 aut
710	2	a Umeå universitetb Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 org
773	0	t Natureg 436:7052, s. 807-11q 436:7052<807-11x 1476-4687
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16094360&dopt=Citation
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16702

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Av författaren/redakt...: Hemann, Michael ...; Bric, Anka; Teruya-Feldstein ...; Herbst, Andreas; Nilsson, Jonas A; Cordon-Cardo, Ca ...; visa fler...; Cleveland, John ...; Tansey, William ...; Lowe, Scott W; visa färre...

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Av lärosätet: Umeå universitet

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