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WFRF:(Drevon C. A.)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003822naa a2200541 4500
001oai:DiVA.org:uu-141348
003SwePub
008110111s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1413482 URI
0247 a https://doi.org/10.1038/ijo.2010.2092 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tierney, A C4 aut
2451 0a Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE :b a European randomized dietary intervention study
264 c 2010-10-12
264 1b Springer Science and Business Media LLC,c 2011
338 a print2 rdacarrier
520 a Background:Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on insulin sensitivity (SI) and on other components of the MetS.Objective:This study determined the relative efficacy of reducing dietary SFA, by isoenergetic alteration of the quality and quantity of dietary fat, on risk factors associated with MetS.Design:A free-living, single-blinded dietary intervention study.Subjects and Methods:MetS subjects (n=417) from eight European countries completed the randomized dietary intervention study with four isoenergetic diets distinct in fat quantity and quality: high-SFA; high-monounsaturated fatty acids and two low-fat, high-complex carbohydrate (LFHCC) diets, supplemented with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) (1.2 g per day) or placebo for 12 weeks. SI estimated from an intravenous glucose tolerance test (IVGTT) was the primary outcome measure. Lipid and inflammatory markers associated with MetS were also determined.Results:In weight-stable subjects, reducing dietary SFA intake had no effect on SI, total and low-density lipoprotein cholesterol concentration, inflammation or blood pressure in the entire cohort. The LFHCC n-3 PUFA diet reduced plasma triacylglycerol (TAG) and non-esterified fatty acid concentrations (P<0.01), particularly in men.Conclusion:There was no effect of reducing SFA on SI in weight-stable obese MetS subjects. LC n-3 PUFA supplementation, in association with a low-fat diet, improved TAG-related MetS risk profiles.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a MEDICINE
653 a MEDICIN
7001 a McMonagle, J4 aut
7001 a Shaw, D I4 aut
7001 a Gulseth, H L4 aut
7001 a Helal, O4 aut
7001 a Saris, W H M4 aut
7001 a Paniagua, J A4 aut
7001 a Gołąbek-Leszczyñska, I4 aut
7001 a Defoort, C4 aut
7001 a Williams, C M4 aut
7001 a Karsltröm, Britau Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)britkarl
7001 a Vessby, Bengtu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)bengvess
7001 a Dembinska-Kiec, A4 aut
7001 a López-Miranda, J4 aut
7001 a Blaak, E E4 aut
7001 a Drevon, C A4 aut
7001 a Gibney, M J4 aut
7001 a Lovegrove, J A4 aut
7001 a Roche, H M4 aut
7102 a Uppsala universitetb Klinisk nutrition och metabolism4 org
7730 t International Journal of Obesityd : Springer Science and Business Media LLCg 35:6, s. 800-809q 35:6<800-809x 0307-0565x 1476-5497
8564 u https://www.nature.com/articles/ijo2010209.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-141348
8564 8u https://doi.org/10.1038/ijo.2010.209

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