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  • Ong, Jason J.Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK (författare)

Comparison of gastrointestinal side effects from different doses of azithromycin for the treatment of gonorrhoea

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-04-13
  • Oxford University Press,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-98557
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98557URI
  • https://doi.org/10.1093/jac/dkac118DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agency:National Health and Medical Research Council (NHMRC) of Australia GNT1193955 GNT1172873 GNT1172900 GNT1136117
  • OBJECTIVES: Azithromycin is commonly used to treat Neisseria gonorrhoeae. We compared its gastrointestinal side effects using 1 g single, 2 g single or 2 g split (i.e. 1 g plus 1 g 6-12 h later) dosing, representing our clinic's changing guidelines over the study period.METHODS: We recruited consecutive sexual health clinic patients who received azithromycin (and 500 mg ceftriaxone) for uncomplicated gonorrhoea. Each patient received a text message 48 h after their attendance to complete a questionnaire.RESULTS: Patients received 1 g single (n = 271), 2 g single (218) or 2 g split (105) doses. Vomiting was less common for 1 g versus 2 g single dose [1.1% versus 3.7%; risk difference (RD): -2.6%; 95% CI: -0.2 to -5.4] and 2 g split versus 2 g single dose (0.9% versus 3.7%; RD: -2.8%; 95% CI: -0.3 to -5.8). Nausea was less common for 1 g versus 2 g single dose (13.7% versus 43.1%; RD: -29.5%; 95% CI: -21.7 to -37.2) and 2 g split versus 2 g single dose (16.4% versus 43.1%; RD: -26.8; 95% CI: -17.2 to -36.3). Diarrhoea was less common for 1 g versus 2 g single dose (25.5% versus 50.9%; RD: -25.5%; 95% CI: -17.0 to -33.9) and 2 g split versus 2 g single dose (30.9% versus 50.9%; RD: -20.0; 95% CI: -9.1 to -30.9). Almost all were willing to retake the same dosing for gonorrhoea in the future: 97% for 1 g single; 94% for 2 g single; and 97% for 2 g split dose.CONCLUSIONS: Azithromycin 2 g split dose for gonorrhoea resulted in significantly less vomiting, nausea and diarrhoea than a 2 g single dose.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Aguirre, IvetteMelbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (författare)
  • Unemo, Magnus,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Institute for Global Health, University College London (UCL), London, UK(Swepub:oru)muo (författare)
  • Kong, Fabian Y. S.Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia (författare)
  • Fairley, Christopher K.Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (författare)
  • Hocking, Jane S.Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia (författare)
  • Chow, Eric P. F.Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia (författare)
  • Tieosapjaroen, WaritthaMelbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (författare)
  • Ly, JennyMelbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (författare)
  • Chen, Marcus Y.Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (författare)
  • Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKMelbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Antimicrobial Chemotherapy: Oxford University Press77:7, s. 2011-20160305-74531460-2091

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