Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

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Fältnamn	Indikatorer	Metadata
000		07710naa a2201297 4500
001		oai:DiVA.org:umu-162898
003		SwePub
008		190903s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:d77d5117-30e6-4646-a65f-3a1d75c721fa
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1628982 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-18-03562 DOI
024	7	a https://lup.lub.lu.se/record/d77d5117-30e6-4646-a65f-3a1d75c721fa2 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zhu, Yingu Nanjing Medical University4 aut
245	1 0	a Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer :b A Mendelian Randomization Analysis
264	1	b American Association for Cancer Research (AACR),c 2019
338		a print2 rdacarrier
520		a Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Wei, Yongyue4 aut
700	1	a Zhang, Ruyang4 aut
700	1	a Dong, Xuesi4 aut
700	1	a Shen, Sipeng4 aut
700	1	a Zhao, Yang4 aut
700	1	a Bai, Jianling4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Caporaso, Neil E.4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Zhu, Bin4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Gu, Fangyi4 aut
700	1	a Lam, Stephen4 aut
700	1	a Tsao, Ming-Sound4 aut
700	1	a Shepherd, Frances A.4 aut
700	1	a Tardon, Adonina4 aut
700	1	a Fernandez-Somoano, Ana4 aut
700	1	a Fernandez-Tardon, Guillermo4 aut
700	1	a Chen, Chuu Harvard University,Nanjing Medical University4 aut
700	1	a Barnett, Matthew J.4 aut
700	1	a Doherty, Jennifer4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Brennan, Paul4 aut
700	1	a Mckay, James D.4 aut
700	1	a Carreras-Torres, Robert4 aut
700	1	a Muley, Thomas4 aut
700	1	a Risch, Angela4 aut
700	1	a Wichmann, Heunz-Erich4 aut
700	1	a Bickeboeller, Heike4 aut
700	1	a Rosenberger, Albert4 aut
700	1	a Rennert, Gad4 aut
700	1	a Saliba, Walid4 aut
700	1	a Arnold, Susanne M.4 aut
700	1	a Field, John K.4 aut
700	1	a Davies, Michael P. A.4 aut
700	1	a Marcus, Michael W.4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Wilkens, Lynne R.4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700	1	a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups4 aut0 (Swepub:lu)med-hsb
700	1	a Hung, Rayjean J.4 aut
700	1	a Liu, Geoffrey4 aut
700	1	a Brhane, Yonathan4 aut
700	1	a Kachuri, Linda4 aut
700	1	a Andrew, Angeline S.4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a van der Heijden, Erik H. F. M.4 aut
700	1	a Haugen, Aage4 aut
700	1	a Zienolddiny, Shanbeh4 aut
700	1	a Skaug, Vidar4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Johansson, Mikaelu Umeå universitet,Onkologi4 aut
700	1	a Woll, Penella J.4 aut
700	1	a Cox, Angela4 aut
700	1	a Taylor, Fiona4 aut
700	1	a Teare, Dawn M.4 aut
700	1	a Lazarus, Philip4 aut
700	1	a Schabath, Matthew B.4 aut
700	1	a Aldrich, Melinda C.4 aut
700	1	a Houlston, Richard S.4 aut
700	1	a McLaughlin, John4 aut
700	1	a Stevens, Victoria L.4 aut
700	1	a Shen, Hongbing4 aut
700	1	a Hu, Zhibin4 aut
700	1	a Dai, Juncheng4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Han, Younghun4 aut
700	1	a Zhu, Dakai4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Chen, Feng4 aut
700	1	a Christiani, David C.4 aut
710	2	a Nanjing Medical Universityb Harvard University4 org
710	2	a et al.
773	0	t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 28:5, s. 935-942q 28:5<935-942x 1055-9965x 1538-7755
856	4	u http://dx.doi.org/10.1158/1055-9965.EPI-18-0356y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162898
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-18-0356
856	4 8	u https://lup.lub.lu.se/record/d77d5117-30e6-4646-a65f-3a1d75c721fa

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Cancer Epidemiology, Biomarkers and Prevention (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; visa fler...; Bai, Jianling; Albanes, Demetri ...; Caporaso, Neil E ...; Landi, Maria Ter ...; Zhu, Bin; Chanock, Stephen ...; Gu, Fangyi; Lam, Stephen; Tsao, Ming-Sound; Shepherd, France ...; Tardon, Adonina; Fernandez-Somoan ...; Fernandez-Tardon ...; Chen, Chu; Barnett, Matthew ...; Doherty, Jennife ...; Bojesen, Stig E.; Johansson, Matti ...; Brennan, Paul; Mckay, James D.; Carreras-Torres, ...; Muley, Thomas; Risch, Angela; Wichmann, Heunz- ...; Bickeboeller, He ...; Rosenberger, Alb ...; Rennert, Gad; Saliba, Walid; Arnold, Susanne ...; Field, John K.; Davies, Michael ...; Marcus, Michael ...; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loi ...; Wilkens, Lynne R ...; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline ...; Duell, Eric J.; Kiemeney, Lamber ...; van der Heijden, ...; Haugen, Aage; Zienolddiny, Sha ...; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikae ...; Woll, Penella J.; Cox, Angela; Taylor, Fiona; Teare, Dawn M.; Lazarus, Philip; Schabath, Matthe ...; Aldrich, Melinda ...; Houlston, Richar ...; McLaughlin, John; Stevens, Victori ...; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christophe ...; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, Davi ...; visa färre...

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