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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005179naa a2200421 4500
001oai:DiVA.org:umu-170433
003SwePub
008200505s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-410069
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1704332 URI
0247 a https://doi.org/10.1016/j.antiviral.2019.1046762 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4100692 URI
040 a (SwePub)umud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gaunt, Michael W.u London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.4 aut
2451 0a Recombination of B- and T-cell epitope-rich loci from Aedes- and Culex-borne flaviviruses shapes Zika virus epidemiology
264 1b Elsevier,c 2020
338 a print2 rdacarrier
520 a Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Cu/ex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic incongruence in relation to: DENV T-cell epitope maps experimentally identified ex vivo, published B-cell epitope loci, and CD8(+) T-cell epitopes predicted in silico for mosquito-borne flaviviruses. Our findings demonstrate that the ZIKV proteome is a hybrid of Aedes-borne DENV proteins interspersed amongst Cu/ex-borne flavivirus proteins derived through independent interspecies recombination events. These analyses infer that DENV-associated proteins in the ZIKV hybrid proteome generated immunodominant human B-cell responses, whereas ZIKV recombinant derived Cu/ex-borne flavivirus-associated proteins generated immunodominant CD8(+) and/or CD4(+) T-cell responses. In silico CD8(+) T-cell epitope ZIKV cross-reactive prediction analyses verified this observation. We propose that by acquiring cytotoxic T-cell epitope-rich regions from Cu/ex-borne flaviviruses, ZIKV evaded DENV-generated T-cell immune cross-protection. Thus, Cu/ex-borne flaviviruses, including West Nile virus and Japanese encephalitis virus, might induce cross-protective T-cell responses against ZIKV. This would explain why explosive ZIKV epidemics occurred in DENV-endemic regions of Micronesia, Polynesia and the Americas where Cu/ex-borne flavivirus outbreaks are infrequent and why ZIKV did not cause major epidemics in Asia where Culex-borne flaviviruses are widespread.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
7001 a Gubler, Duane J.u Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore.4 aut
7001 a Pettersson, John,d 1981-u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.4 aut0 (Swepub:uu)johpe964
7001 a Kuno, Gorou 1648 Collindale Dr, Ft Collins, CO 80525 USA.4 aut
7001 a Wilder-Smith, Anneliesu Umeå universitet,Epidemiologi och global hälsa,London School of Hygiene and Tropical Medicine, Keppel Street, London, UK,London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.;Umea Univ, Dept Publ Hlth & Clin Med, Epidemiol & Publ Hlth, Umea, Sweden.;Heidelberg Univ, Heidelberg Inst Global Hlth, Heidelberg, Germany.4 aut0 (Swepub:umu)anwi0099
7001 a de Lamballerie, Xavieru Aix Marseille Univ, UMR Unite Virus Emergents, IHU Mediterranee Infect 1207, INSERM,IRD 190, Marseille, France.4 aut
7001 a Gould, Ernest A.u Aix Marseille Univ, UMR Unite Virus Emergents, IHU Mediterranee Infect 1207, INSERM,IRD 190, Marseille, France.4 aut
7001 a Falconar, Andrew K.u Univ Norte, Dept Med, Barranquilla, Colombia.4 aut
7102 a London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.b Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore.4 org
7730 t Antiviral Researchd : Elsevierg 174q 174x 0166-3542x 1872-9096
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170433
8564 8u https://doi.org/10.1016/j.antiviral.2019.104676
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-410069

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