WFRF:(Guillou P. J.)
Sökning: WFRF:(Guillou P. J.) > (2020-2024) > The Regenerative Ef...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02727naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:144587958 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1445879582 URI |
| 024 | 7 | a https://doi.org/10.1007/s13311-020-00915-52 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Chalfouh, C4 aut |
| 245 | 1 0 | a The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect |
| 264 | c 2020-08-27 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is no therapeutic intervention offering a complete recovery. Here, we report that repetitive trans-spinal magnetic stimulation (rTSMS) can be a noninvasive SCI treatment that enhances tissue repair and functional recovery. Several techniques including immunohistochemical, behavioral, cells cultures, and proteomics have been performed. Moreover, different lesion paradigms, such as acute and chronic phase following SCI in wild-type and transgenic animals at different ages (juvenile, adult, and aged), have been used. We demonstrate that rTSMS modulates the lesion scar by decreasing fibrosis and inflammation and increases proliferation of spinal cord stem cells. Our results demonstrate also that rTSMS decreases demyelination, which contributes to axonal regrowth, neuronal survival, and locomotor recovery after SCI. This research provides evidence that rTSMS induces therapeutic effects in a preclinical rodent model and suggests possible translation to clinical application in humans. | |
| 700 | 1 | a Guillou, C4 aut |
| 700 | 1 | a Hardouin, J4 aut |
| 700 | 1 | a Delarue, Q4 aut |
| 700 | 1 | a Li, Xu Karolinska Institutet4 aut |
| 700 | 1 | a Duclos, C4 aut |
| 700 | 1 | a Schapman, D4 aut |
| 700 | 1 | a Marie, JP4 aut |
| 700 | 1 | a Cosette, P4 aut |
| 700 | 1 | a Guerout, N4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsd : Springer Science and Business Media LLCg 17:4, s. 2069-2088q 17:4<2069-2088x 1878-7479 |
| 773 | 0 | t Neurotherapeuticsd : Springer Science and Business Media LLCg 17:4, s. 2069-2088q 17:4<2069-2088x 1933-7213 |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s13311-020-00915-5.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144587958 |
| 856 | 4 8 | u https://doi.org/10.1007/s13311-020-00915-5 |
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