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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003771naa a2200409 4500
001oai:DiVA.org:liu-93396
003SwePub
008130531s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-933962 URI
0247 a https://doi.org/10.1016/j.bbrc.2013.03.0142 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Luo, Limanu Peking University, Peoples R China4 aut
2451 0a Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow
264 1b Elsevier,c 2013
338 a print2 rdacarrier
500 a Funding Agencies|Beijing Natural Science Foundation|7112130|Major Basic Research Development Program of Peoples Republic of China|2011CB5039042012CB517806|National Natural Science Foundation of China|81121061810701 1131130030|
520 a Pulmonary hypertension (PH) is an important pathophysiological process in the development of many diseases. However, the mechanism responsible for the development of PH remains unknown. The objective of the study was to explore the possible impact of sulfur dioxide (SO2) on the endogenous hydrogen sulfide (H2S) pathway in rats with PH induced by high pulmonary blood flow. Compared with sham group, the systolic pulmonary artery pressure (SPAP) in the shunt group was significantly increased, along with the increased percentage of muscularized arteries and partially muscularized arteries of small pulmonary arteries. Compared with the shunt group, SPAP in the shunt + SO2 group was significantly decreased, and the percentage of muscularized pulmonary arteries was also decreased. Additionally, rats that developed PH had significantly lower levels of SO2 concentration, aspartate aminotransferase (AAT) activity, protein and mRNA expressions of AAT2 in pulmonary tissues. Administration of an SO2 donor could alleviate the elevated pulmonary arterial pressure and decrease the muscularization of pulmonary arteries. At the same time, it increased the H2S production, protein expression of cystathionine-gamma-lyase (CSE), mRNA expression of CSE, mercaptopyruvate transsulphurase (MPST) and cystathionine-beta-synthase (CBS) in the pulmonary tissue of the rats. The results suggested that endogenous SO2/AAT2 pathway and the endognous H2S production were downregulated in rats with PH induced by high pulmonary blood flow. However, SO2 could reduce pulmonary arterial pressure and improve the pulmonary vascular pathological changes in association with upregulating endogenous H2S pathway.
653 a Pulmonary hypertension
653 a Pulmonary vascular remodeling
653 a Sulfur dioxide
653 a Hydrogen sulfide
653 a MEDICINE
653 a MEDICIN
7001 a Liu, Dieu Peking University, Peoples R China4 aut
7001 a Tang, Chaoshuu Peking University, Peoples R China4 aut
7001 a Du, Junbaou Peking University, Peoples R China4 aut
7001 a Dong Liu, Angieu Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet4 aut
7001 a Holmberg, Lukasu Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet4 aut
7001 a Jin, Hongfangu Peking University, Peoples R China4 aut
7102 a Peking University, Peoples R Chinab Institutionen för medicin och hälsa4 org
7730 t Biochemical and Biophysical Research Communications - BBRCd : Elsevierg 433:4, s. 519-525q 433:4<519-525x 0006-291Xx 1090-2104
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93396
8564 8u https://doi.org/10.1016/j.bbrc.2013.03.014

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