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Sökning: WFRF:(Husebye Eystein Sverre) > (2020-2023) > Plasma-Metanephrine...

Plasma-Metanephrines in Patients with Autoimmune Addison's Disease with and without Residual Adrenocortical Function

Åkerman, Anna-Karin (författare)
Department of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
Sævik, Åse Bjorvatn (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway
Thorsby, Per Medbøe (författare)
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, 0372 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, 0372 Oslo, Norway
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Methlie, Paal (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway
Quinkler, Marcus (författare)
Endocrinology in Charlottenburg, 10627 Berlin, Germany
Jørgensen, Anders Palmstrøm (författare)
Department of Endocrinology, Oslo University Hospital, 0372 Oslo, Norway
Höybye, Charlotte (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden
Debowska, Aleksandra J. (författare)
Department of Medicine, Vestfold Hospital Trust, 3103 Tønsberg, Norway
Nedrebø, Bjørn Gunnar (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; Department of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway
Dahle, Anne Lise (författare)
Department of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway
Carlsen, Siri (författare)
Department of Endocrinology, Stavanger University Hospital, 4068 Stavanger, Norway
Tomkowicz, Aneta (författare)
Department of Medicine, Sørlandet Hospital, 4604 Kristiansand, Norway
Sollid, Stina Therese (författare)
Department of Medicine, Drammen Hospital, Vestre Viken Health Trust, 3004 Drammen, Norway
Nermoen, Ingrid (författare)
Department of Endocrinology, Akershus University Hospital, 1478 Lørenskog, Norway
Grønning, Kaja (författare)
Department of Endocrinology, Akershus University Hospital, 1478 Lørenskog, Norway
Dahlqvist, Per (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Grimnes, Guri (författare)
Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, 9037 Tromsø, Norway
Skov, Jakob (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
Finnes, Trine (författare)
Section of Endocrinology, Innlandet Hospital Trust, 2381 Hamar, Norway
Wahlberg, Jeanette, 1969- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden,Department of Medicine, Örebro University Hospital, Örebro, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Holte, Synnøve Emblem (författare)
Department of Medicine, Sørlandet Hospital, 4838 Arendal, Norway
Simunkova, Katerina (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
Kämpe, Olle (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
Husebye, Eystein Sverre (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
Øksnes, Marianne (författare)
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
Bensing, Sophie (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden
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Department of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; KG. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway (creator_code:org_t)
MDPI, 2023
2023
Engelska.
Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 12:10
Relaterad länk:
https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison's disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma metanephrines and any changes following stimulation with cosyntropin.METHODS: We included 50 patients with verified RAF and 20 patients without RAF who served as controls upon cosyntropin stimulation testing. The patients had abstained from glucocorticoid and fludrocortisone replacement > 18 and 24 h, respectively, prior to morning blood sampling. The samples were obtained before and 30 and 60 min after cosyntropin stimulation and analyzed for serum cortisol, plasma metanephrine (MN), and normetanephrine (NMN) by liquid-chromatography tandem-mass pectrometry (LC-MS/MS).RESULTS: Among the 70 patients with AAD, MN was detectable in 33%, 25%, and 26% at baseline, 30 min, and 60 min after cosyntropin stimulation, respectively. Patients with RAF were more likely to have detectable MN at baseline (p = 0.035) and at the time of 60 min (p = 0.048) compared to patients without RAF. There was a positive correlation between detectable MN and the level of cortisol at all time points (p = 0.02, p = 0.04, p < 0.001). No difference was noted for NMN levels, which remained within the normal reference ranges.CONCLUSION: Even very small amounts of endogenous cortisol production affect MN levels in patients with AAD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Addison’s disease
adrenal cortex
adrenal medulla
catecholamines
metanephrines
residual function

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