Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets

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Multi-component assessment of chronic obstructive pulmonary disease : an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets

Jones, Rupert C. (författare): Clinical Trials and Population Studies, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK,Univ Plymouth, Peninsula Sch Med, Clin Trials & Populat Studies, ITTC Bldg N14,Plymouth Sci Pk, Plymouth PL4 8AA, Devon, England.;Univ Plymouth, Peninsula Sch Dent, Clin Trials & Populat Studies, ITTC Bldg N14,Plymouth Sci Pk, Plymouth PL4 8AA, Devon, England.

Price, David (författare): Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK,Univ Aberdeen, Ctr Acad Primary Care, Aberdeen, Scotland.

Chavannes, Niels H. (författare): Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands,Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands.

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Lee, Amanda J. (författare): Medical Statistics Team, Applied Health Sciences, University of Aberdeen, Aberdeen, UK,Univ Aberdeen, Appl Hlth Sci, Med Stat Team, Aberdeen, Scotland.

Hyland, Michael E. (författare): School of Psychology, Plymouth University, Plymouth, UK,Univ Plymouth, Sch Psychol, Plymouth PL4 8AA, Devon, England.

Ställberg, Björn (författare): Uppsala universitet,Allmänmedicin och preventivmedicin

Lisspers, Karin (författare): Uppsala universitet,Allmänmedicin och preventivmedicin

Sundh, Josefin, 1972- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Respiratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, Dept Resp Med, Orebro Univ Hosp, SE-70182 Orebro, Sweden.

van der Molen, Thys (författare): University Medical Center Groningen, Department of General Practice, University of Groningen, Groningen, The Netherlands,Univ Groningen, Univ Med Ctr Groningen, Dept Gen Practice, Groningen, Netherlands.

Tsiligianni, Ioanna (författare): University Medical Center Groningen, Department of General Practice, University of Groningen, Groningen, The Netherlands,Univ Groningen, Univ Med Ctr Groningen, Dept Gen Practice, Groningen, Netherlands.

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Clinical Trials and Population Studies, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK Univ Plymouth, Peninsula Sch Med, Clin Trials & Populat Studies, ITTC Bldg N14,Plymouth Sci Pk, Plymouth PL4 8AA, Devon, England;Univ Plymouth, Peninsula Sch Dent, Clin Trials & Populat Studies, ITTC Bldg N14,Plymouth Sci Pk, Plymouth PL4 8AA, Devon, England. (creator_code:org_t)

2016-04-07
2016
Engelska.
Ingår i: npj Primary Care Respiratory Medicine. - London, United Kingdom : Nature Publishing Group. - 2055-1010. ; 26

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Suitable tools for assessing the severity of chronic obstructive pulmonary disease (COPD) include multi-component indices and the global initiative for chronic obstructive lung disease (GOLD) categories. The aim of this study was to evaluate the dyspnoea, obstruction, smoking, exacerbation (DOSE) and the age, dyspnoea, obstruction (ADO) indices and GOLD categories as measures of current health status and future outcomes in COPD patients. This was an observational cohort study comprising 5,114 primary care COPD patients across three databases from UK, Sweden and Holland. The associations of DOSE and ADO indices with (i) health status using the Clinical COPD Questionnaire (CCQ) and St George's Respiratory Questionnaire (SGRQ) and COPD Assessment test (CAT) and with (ii) current and future exacerbations, admissions and mortality were assessed in GOLD categories and DOSE and ADO indices. DOSE and ADO indices were significant predictors of future exacerbations: incident rate ratio was 1.52 (95% confidence intervals 1.46-1.57) for DOSE, 1.16 (1.12-1.20) for ADO index and 1.50 (1.33-1.68) and 1.23 (1.10-1.39), respectively, for hospitalisations. Negative binomial regression showed that the DOSE index was a better predictor of future admissions than were its component items. The hazard ratios for mortality were generally higher for ADO index groups than for DOSE index groups. The GOLD categories produced widely differing assessments for future exacerbation risk or for hospitalisation depending on the methods used to calculate them. None of the assessment systems were excellent at predicting future risk in COPD; the DOSE index appears better than the ADO index for predicting many outcomes, but not mortality. The GOLD categories predict future risk inconsistently. The DOSE index and the GOLD categories using exacerbation frequency may be used to identify those at high risk for exacerbations and admissions.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)

Nyckelord

Pulmonary Medicine
Lungmedicin

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Av författaren/redakt...: Jones, Rupert C.; Price, David; Chavannes, Niels ...; Lee, Amanda J.; Hyland, Michael ...; Ställberg, Björn; visa fler...; Lisspers, Karin; Sundh, Josefin, ...; van der Molen, T ...; Tsiligianni, Ioa ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Allmänmedicin

Artiklar i publikationen: npj Primary Care ...

Av lärosätet: Örebro universitet; Uppsala universitet

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