Mapping uncertainty in genomics

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Fältnamn	Indikatorer	Metadata
000		03360naa a2200397 4500
001		oai:DiVA.org:uu-341314
003		SwePub
008		180207s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:137405036
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3413142 URI
024	7	a https://doi.org/10.1080/13669877.2016.12153442 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1374050362 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Howard, Heidi Carmenu Uppsala universitet,Centrum för forsknings- och bioetik4 aut0 (Swepub:uu)heiho221
245	1 0	a Mapping uncertainty in genomics
264		c 2017-08-22
264	1	b ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD,c 2018
338		a print2 rdacarrier
520		a The relatively novel and dynamic science of genomics holds many unknowns for stakeholders, and in particular for researchers and clinicians, as well as for participants and patients. At a time when many authors predict a future in which genomic medicine will be the norm, it is particularly relevant to discuss the unknowns surrounding genetics and genomics, including the notions of risk and uncertainty. This article will present a discussion regarding the uncertainty pertaining specifically to high throughput sequencing approaches, including the topic of incidental findings. This discussion will be guided by a taxonomy of uncertainty conceptualised around three areas of uncertainty: the source of uncertainty, the issues of uncertainty and the loci of uncertainty. This taxonomy can be used as a tool by all stakeholders involved in genomics to help further understand and anticipate uncertainties in genomics. Furthermore, to better contextualize this information, and also because this contribution is born out of an international project titled Mind the Risk', which addresses risk information in genetics and genomics from many different disciplinary perspectives, another aim of this article is to briefly present the basic issues pertaining to the unknowns, risks, and uncertainties of genetics as well as genomics for an audience of non-geneticists. Ultimately, the mapping out of uncertainty in genomics should allow for a better characterization of the uncertainty and consequently for a better management and communication of these uncertainties to end-users (research participants and patients).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Medicinsk etik0 (SwePub)303102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Medical Ethics0 (SwePub)303102 hsv//eng
653		a genetics
653		a genomics
653		a uncertainty
653		a taxonomy of uncertainty
653		a incidental findings
700	1	a Iwarsson, Eriku Karolinska Institutet4 aut
710	2	a Uppsala universitetb Centrum för forsknings- och bioetik4 org
773	0	t Journal of Risk Researchd : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTDg 21:2, s. 117-128q 21:2<117-128x 1366-9877x 1466-4461
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341314
856	4 8	u https://doi.org/10.1080/13669877.2016.1215344
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:137405036

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Av författaren/redakt...: Howard, Heidi Ca ...; Iwarsson, Erik

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Medicinsk etik

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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