Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

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Fältnamn	Indikatorer	Metadata
000		05347naa a2201033 4500
001		oai:DiVA.org:uu-86913
003		SwePub
008		081209s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:118088730
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-869132 URI
024	7	a https://doi.org/10.1038/ng.2692 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1180887302 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aulchenko, Yurii S4 aut
245	1 0	a Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
264		c 2008-12-07
264	1	b Springer Science and Business Media LLC,c 2009
338		a print2 rdacarrier
520		a Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 x 10(-8)), including 16 loci that were identified by previous GWA studies. The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)). For three loci, effect sizes differed significantly by sex. Genetic risk scores based on lipid loci explain up to 4.8% of variation in lipids and were also associated with increased intima media thickness (P = 0.001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors.
653		a MEDICINE
653		a MEDICIN
653		a Genetics
653		a Genetik
700	1	a Ripatti, Samuli4 aut
700	1	a Lindqvist, Ida4 aut
700	1	a Boomsma, Dorret4 aut
700	1	a Heid, Iris M4 aut
700	1	a Pramstaller, Peter P4 aut
700	1	a Penninx, Brenda W J H4 aut
700	1	a Janssens, A Cecile J W4 aut
700	1	a Wilson, James F4 aut
700	1	a Spector, Tim4 aut
700	1	a Martin, Nicholas G4 aut
700	1	a Pedersen, Nancy Lu Karolinska Institutet4 aut
700	1	a Kyvik, Kirsten Ohm4 aut
700	1	a Kaprio, Jaakko4 aut
700	1	a Hofman, Albert4 aut
700	1	a Freimer, Nelson B4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll
700	1	a Campbell, Harry4 aut
700	1	a Rudan, Igor4 aut
700	1	a Johansson, Åsau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)asjoh108
700	1	a Marroni, Fabio4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Jonasson, Ingeru Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ingejona
700	1	a Pattaro, Cristian4 aut
700	1	a Wright, Alan4 aut
700	1	a Hastie, Nick4 aut
700	1	a Pichler, Irene4 aut
700	1	a Hicks, Andrew A4 aut
700	1	a Falchi, Mario4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a de Geus, Eco J C4 aut
700	1	a Montgomery, Grant W4 aut
700	1	a Whitfield, John4 aut
700	1	a Magnusson, Patriku Karolinska Institutet4 aut
700	1	a Saharinen, Juha4 aut
700	1	a Perola, Markus4 aut
700	1	a Silander, Kaisa4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Sijbrands, Eric J G4 aut
700	1	a Uitterlinden, Andre G4 aut
700	1	a Witteman, Jacqueline C M4 aut
700	1	a Oostra, Ben A4 aut
700	1	a Elliott, Paul4 aut
700	1	a Ruokonen, Aimo4 aut
700	1	a Sabatti, Chiara4 aut
700	1	a Gieger, Christian4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Kronenberg, Florian4 aut
700	1	a Döring, Angela4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Smit, Johannes H4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Peltonen, Leena4 aut
710	2	a Karolinska Institutetb Institutionen för genetik och patologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 41:1, s. 47-55q 41:1<47-55x 1061-4036x 1546-1718
856	4	u https://research.vu.nl/ws/files/2401162/Aulchenko%20NG%202009.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-86913
856	4 8	u https://doi.org/10.1038/ng.269
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:118088730

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Av författaren/redakt...: Aulchenko, Yurii ...; Ripatti, Samuli; Lindqvist, Ida; Boomsma, Dorret; Heid, Iris M; Pramstaller, Pet ...; visa fler...; Penninx, Brenda ...; Janssens, A Ceci ...; Wilson, James F; Spector, Tim; Martin, Nicholas ...; Pedersen, Nancy ...; Kyvik, Kirsten O ...; Kaprio, Jaakko; Hofman, Albert; Freimer, Nelson ...; Jarvelin, Marjo- ...; Gyllensten, Ulf; Campbell, Harry; Rudan, Igor; Johansson, Åsa; Marroni, Fabio; Hayward, Carolin ...; Vitart, Veroniqu ...; Jonasson, Inger; Pattaro, Cristia ...; Wright, Alan; Hastie, Nick; Pichler, Irene; Hicks, Andrew A; Falchi, Mario; Willemsen, Gonne ...; Hottenga, Jouke- ...; de Geus, Eco J C; Montgomery, Gran ...; Whitfield, John; Magnusson, Patri ...; Saharinen, Juha; Perola, Markus; Silander, Kaisa; Isaacs, Aaron; Sijbrands, Eric ...; Uitterlinden, An ...; Witteman, Jacque ...; Oostra, Ben A; Elliott, Paul; Ruokonen, Aimo; Sabatti, Chiara; Gieger, Christia ...; Meitinger, Thoma ...; Kronenberg, Flor ...; Döring, Angela; Wichmann, H-Eric ...; Smit, Johannes H; McCarthy, Mark I; van Duijn, Corne ...; Peltonen, Leena; visa färre...

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