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Sökning: WFRF:(Kihlberg Johan 1970 ) > Quantifying differe...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005626naa a2200421 4500
001oai:DiVA.org:liu-73624
003SwePub
008120110s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123983414
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-736242 URI
0247 a https://doi.org/10.1007/s00330-011-2302-42 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239834142 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dahlqvist Leinhard, Olof,d 1978-u Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Hälsouniversitetet4 aut0 (Swepub:liu)oloda24
2451 0a Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA :b a pilot study
264 c 2011-10-09
264 1b Springer Berlin/Heidelberg,c 2012
338 a electronic2 rdacarrier
500 a The previous status of this article was Manuscript and the working titles was Liver Specific Gd-EOB-DTPA vs. Gd-BOPTA Uptake in Healthy Subjects: A Novel and Quantitative MRI Analysis of Hepatic Uptake and Vascular Enhancement and Hepatic Uptake of Gd-EOB-DTPA in Patients with Varying Degree of Hepatobiliary Disease.
520 a Objectives   To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI. Methods   Ten healthy volunteers were prospectively recruited and 21 patients with suspected hepatobiliary disease were retrospectively evaluated. All subjects were examined with DCE-MRI using 0.025 mmol/kg of Gd-EOB-DTPA. The healthy volunteers underwent an additional examination using 0.05 mmol/kg of Gd-BOPTA. The signal intensities (SI) of liver and spleen parenchyma were obtained from unenhanced and enhanced acquisitions. Using pharmacokinetic models of the liver and spleen, and an SI rescaling procedure, a hepatic uptake rate, K Hep, estimate was derived. The K Hep values for Gd-EOB-DTPA were then studied in relation to those for Gd-BOPTA and to a clinical classification of the patient’s hepatobiliary dysfunction. Results   K Hep estimated using Gd-EOB-DTPA showed a significant Pearson correlation with K Hep estimated using Gd-BOPTA (r = 0.64; P < 0.05) in healthy subjects. Patients with impaired hepatobiliary function had significantly lower K Hep than patients with normal hepatobiliary function (K Hep = 0.09 ± 0.05 min-1 versus K Hep = 0.24 ± 0.10 min−1; P < 0.01). Conclusions   A new procedure for quantifying the hepatocyte-specific uptake of T 1-enhancing contrast agent was demonstrated and used to show that impaired hepatobiliary function severely influences the hepatic uptake of Gd-EOB-DTPA. Key Points   • The liver uptake of contrast agents may be measured with standard clinical MRI. • Calculation of liver contrast agent uptake is improved by considering splenic uptake. • Liver function affects the uptake of the liver-specific contrast agent Gd-EOB-DTPA. • Hepatic uptake of two contrast agents (Gd-EOB-DTPA, Gd-BOPTA) is correlated in healthy individuals. • This method can be useful for determining liver function, e.g. before hepatic surgery
653 a Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid – Gadobenate Dimeglumine – Dynamic contrast-enhanced MRI – Pharmacokinetics – Liver
7001 a Dahlström, Nils,d 1969-u Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)nilda87
7001 a Kihlberg, Johan,d 1970-u Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)johki53
7001 a Sandström, Peru Linköpings universitet,Hälsouniversitetet,Kirurgi4 aut0 (Swepub:liu)persa07
7001 a Brismar, Torkelu Karolinska Institutet,Department of Clinical Science, Intervention and Technology at Karolinska Institutet, Division of Medical Imaging and Technology, Karolinska University Hospital in Huddinge, Stockholm, Sweden4 aut
7001 a Smedby, Örjan,d 1956-u Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)orjsm14
7001 a Lundberg, Peter,d 1958-u Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Medicinsk radiologi,Hälsouniversitetet,Radiofysikavdelningen US,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)petlu11
7102 a Linköpings universitetb Centrum för medicinsk bildvetenskap och visualisering, CMIV4 org
7730 t European Radiologyd : Springer Berlin/Heidelbergg 22:3, s. 642-653q 22:3<642-653x 0938-7994x 1432-1084
8564 u https://liu.diva-portal.org/smash/get/diva2:475273/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
8564 u http://liu.diva-portal.org/smash/get/diva2:475273/FULLTEXT01
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73624
8564 8u https://doi.org/10.1007/s00330-011-2302-4
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123983414

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