Genome-wide association identifies multiple ulcerative colitis susceptibility loci

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Fältnamn	Indikatorer	Metadata
000		05305naa a2201045 4500
001		oai:DiVA.org:oru-27403
003		SwePub
008		130206s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:120249612
009		oai:DiVA.org:uu-137595
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-274032 URI
024	7	a https://doi.org/10.1038/ng.5492 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1202496122 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1375952 URI
040		a (SwePub)orud (SwePub)kid (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a McGovern, Dermot P B4 aut
245	1 0	a Genome-wide association identifies multiple ulcerative colitis susceptibility loci
264		c 2010-03-14
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10(-5). Seven of these loci exceeded genome-wide significance (P < 5 x 10(-8)). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a Medicine
653		a Medicin
653		a MEDICINE
700	1	a Gardet, Agnès4 aut
700	1	a Törkvist, Leifu Karolinska Institutet4 aut
700	1	a Goyette, Philippe4 aut
700	1	a Essers, Jonah4 aut
700	1	a Taylor, Kent D4 aut
700	1	a Neale, Benjamin M4 aut
700	1	a Ong, Rick T H4 aut
700	1	a Lagacé, Caroline4 aut
700	1	a Li, Chun4 aut
700	1	a Green, Todd4 aut
700	1	a Stevens, Christine R4 aut
700	1	a Beauchamp, Claudine4 aut
700	1	a Fleshner, Phillip R4 aut
700	1	a Carlson, Marieu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)maricarl
700	1	a D'Amato, Maurou Karolinska Institutet4 aut
700	1	a Halfvarson, Jonas,d 1970-u Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)jshn
700	1	a Hibberd, Martin Lu Karolinska Institutet4 aut
700	1	a Lördal, Mikael4 aut
700	1	a Padyukov, Leonidu Karolinska Institutet4 aut
700	1	a Andriulli, Angelo4 aut
700	1	a Colombo, Elisabetta4 aut
700	1	a Latiano, Anna4 aut
700	1	a Palmieri, Orazio4 aut
700	1	a Bernard, Edmond-Jean4 aut
700	1	a Deslandres, Colette4 aut
700	1	a Hommes, Daan W4 aut
700	1	a de Jong, Dirk J4 aut
700	1	a Stokkers, Pieter C4 aut
700	1	a Weersma, Rinse K4 aut
700	1	a Sharma, Yashoda4 aut
700	1	a Silverberg, Mark S4 aut
700	1	a Cho, Judy H4 aut
700	1	a Wu, Jing4 aut
700	1	a Roeder, Kathryn4 aut
700	1	a Brant, Steven R4 aut
700	1	a Schumm, L Phillip4 aut
700	1	a Duerr, Richard H4 aut
700	1	a Dubinsky, Marla C4 aut
700	1	a Glazer, Nicole L4 aut
700	1	a Haritunians, Talin4 aut
700	1	a Ippoliti, Andy4 aut
700	1	a Melmed, Gil Y4 aut
700	1	a Siscovick, David S4 aut
700	1	a Vasiliauskas, Eric A4 aut
700	1	a Targan, Stephan R4 aut
700	1	a Annese, Vito4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Pettersson, Svenu Karolinska Institutet4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Xavier, Ramnik J4 aut
700	1	a Daly, Mark J4 aut
700	1	a Rioux, John D4 aut
700	1	a Seielstad, Mark4 aut
710	2	a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:4, s. 332-337q 42:4<332-337x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3087600?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27403
856	4 8	u https://doi.org/10.1038/ng.549
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120249612
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137595

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Av författaren/redakt...: McGovern, Dermot ...; Gardet, Agnès; Törkvist, Leif; Goyette, Philipp ...; Essers, Jonah; Taylor, Kent D; visa fler...; Neale, Benjamin ...; Ong, Rick T H; Lagacé, Caroline; Li, Chun; Green, Todd; Stevens, Christi ...; Beauchamp, Claud ...; Fleshner, Philli ...; Carlson, Marie; D'Amato, Mauro; Halfvarson, Jona ...; Hibberd, Martin ...; Lördal, Mikael; Padyukov, Leonid; Andriulli, Angel ...; Colombo, Elisabe ...; Latiano, Anna; Palmieri, Orazio; Bernard, Edmond- ...; Deslandres, Cole ...; Hommes, Daan W; de Jong, Dirk J; Stokkers, Pieter ...; Weersma, Rinse K; Sharma, Yashoda; Silverberg, Mark ...; Cho, Judy H; Wu, Jing; Roeder, Kathryn; Brant, Steven R; Schumm, L Philli ...; Duerr, Richard H; Dubinsky, Marla ...; Glazer, Nicole L; Haritunians, Tal ...; Ippoliti, Andy; Melmed, Gil Y; Siscovick, David ...; Vasiliauskas, Er ...; Targan, Stephan ...; Annese, Vito; Wijmenga, Cisca; Pettersson, Sven; Rotter, Jerome I; Xavier, Ramnik J; Daly, Mark J; Rioux, John D; Seielstad, Mark; visa färre...

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Artiklar i publikationen: Nature Genetics

Av lärosätet: Örebro universitet; Karolinska Institutet; Uppsala universitet

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