WFRF:(Maleki Kimia T.)
Search: WFRF:(Maleki Kimia T.) > Hantavirus Inhibits...
- 5 of 5
- Previous record
- Next record
- To hitlist
Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
- Sola-Riera, Caries (author)
- Gupta, Shawon (author)
-
- Maleki, Kimia T. (author)
- Karolinska Institutet
- show more...
- Saidi, Dale (author)
- Zimmer, Christine L. (author)
- Vangeti, Sindhu (author)
- Rivino, Laura (author)
- Leo, Yee-Sin (author)
- Lye, David Chien (author)
- MacAry, Paul A. (author)
- show less...
- (creator_code:org_t)
- Cell Press, 2019
- 2019
- English.
- In: Cell Reports. - : Cell Press. - 2211-1247. ; 28:8, s. 2124-2139
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Cytotoxic lymphocytes normally kill virus-infected cells by apoptosis induction. Cytotoxic granule-dependent apoptosis induction engages the intrinsic apoptosis pathway, whereas death receptor (DR)-dependent apoptosis triggers the extrinsic apoptosis pathway. Hantaviruses, single-stranded RNA viruses of the order Bunyavirales, induce strong cytotoxic lymphocyte responses in infected humans. Cytotoxic lymphocytes, however, are largely incapable of eradicating hantavirus-infected cells. Here, we show that the prototypic hantavirus, Hantaan virus (HTNV), induces TRAIL production but strongly inhibits TRAIL-mediated extrinsic apoptosis induction in infected cells by downregulating DR5 cell surface expression. Mechanistic analyses revealed that HTNV triggers both 26S proteasome-dependent degradation of DR5 through direct ubiquitination of DR5 and hampers DR5 transport to the cell surface. These results corroborate earlier findings, demonstrating that hantavirus also inhibits cytotoxic cell granule-dependent apoptosis induction. Together, these findings show that HTNV counteracts intrinsic and extrinsic apoptosis induction pathways, providing a defense mechanism utilized by hantaviruses to inhibit cytotoxic cell-mediated eradication of infected cells.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
- 5 of 5
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sola-Riera, Cari ...
- Gupta, Shawon
- Maleki, Kimia T.
- Gonzalez-Rodrigu ...
- Saidi, Dale
- Zimmer, Christin ...
- show more...
- Vangeti, Sindhu
- Rivino, Laura
- Leo, Yee-Sin
- Lye, David Chien
- MacAry, Paul A.
- Ahlm, Clas, 1956 ...
- Smed-Sorensen, A ...
- Joseph, Bertrand
- Bjorkstrom, Nikl ...
- Ljunggren, Hans- ...
- Klingstrom, Jona ...
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Cell Biology
- Articles in the publication
- Cell Reports
- By the university
- Umeå University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
