Sökning: WFRF:(Mebius Reina E) > Neuropilin-1 Is Exp...
Fältnamn | Indikatorer | Metadata |
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000 | 04287naa a2200637 4500 | |
001 | oai:lup.lub.lu.se:7b98bfe3-21b8-4c98-9524-cfa663c12923 | |
003 | SwePub | |
008 | 170301s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:135395196 | |
024 | 7 | a https://lup.lub.lu.se/record/7b98bfe3-21b8-4c98-9524-cfa663c129232 URI |
024 | 7 | a https://doi.org/10.1016/j.celrep.2017.01.0632 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1353951962 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Shikhagaie, Medya Marau University of Amsterdam4 aut0 (Swepub:lu)med-mys |
245 | 1 0 | a Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates |
264 | 1 | b Elsevier BV,c 2017 |
300 | a 13 s. | |
520 | a Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+ ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved in lymphocyte migration in secondary lymphoid tissues via HEVs. NRP1 was also expressed on mouse fetal LTi cells, indicating that NRP1 is a conserved marker for LTi cells. Human NRP1+ ILC3s are primed cells because they express CD45RO and produce higher amounts of cytokines than NRP1− cells, which express CD45RA. The NRP1 ligand vascular endothelial growth factor A (VEGF-A) served as a chemotactic factor for NRP1+ ILC3s. NRP1+ ILC3s are present in lung tissues from smokers and patients with chronic obstructive pulmonary disease, suggesting a role in angiogenesis and/or the initiation of ectopic pulmonary lymphoid aggregates. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a chemotaxis | |
653 | a HEVs | |
653 | a high endothelial venues | |
653 | a human innate lymphoid cells 3 | |
653 | a ILC3 | |
653 | a LA | |
653 | a LTi | |
653 | a lymphoid tissue inducer cells | |
653 | a neuropilin-1 | |
653 | a NRP1 | |
653 | a smoke-induced pulmonary lymphoid aggregates | |
653 | a vascular endothelial growth factor A | |
653 | a VEGF-A | |
700 | 1 | a Björklund, Åsa K.u Karolinska Institute4 aut |
700 | 1 | a Mjösberg, Jennyu Karolinska Institutet,Karolinska Institute4 aut |
700 | 1 | a Erjefält, Jonas S.u Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-jer |
700 | 1 | a Cornelissen, Anne S.u University of Amsterdam4 aut |
700 | 1 | a Ros, Xavier Romerou University of Amsterdam4 aut |
700 | 1 | a Bal, Suzanne M.u University of Amsterdam4 aut |
700 | 1 | a Koning, Jasper J.u Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Mebius, Reina E.u Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Mori, Michikou Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups4 aut0 (Swepub:lu)med-mhm |
700 | 1 | a Bruchard, Melanieu University of Amsterdam4 aut |
700 | 1 | a Blom, Biancau University of Amsterdam4 aut |
700 | 1 | a Spits, Hergenu University of Amsterdam4 aut |
710 | 2 | a Karolinska Instituteb University of Amsterdam4 org |
773 | 0 | t Cell Reportsd : Elsevier BVg 18:7, s. 1761-1773q 18:7<1761-1773x 2211-1247 |
856 | 4 | u http://dx.doi.org/10.1016/j.celrep.2017.01.063x freey FULLTEXT |
856 | 4 | u http://www.cell.com/article/S2211124717301201/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/7b98bfe3-21b8-4c98-9524-cfa663c12923 |
856 | 4 8 | u https://doi.org/10.1016/j.celrep.2017.01.063 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135395196 |
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