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FältnamnIndikatorerMetadata
00005591naa a2200505 4500
001oai:DiVA.org:uu-453041
003SwePub
008210920s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4530412 URI
0247 a https://doi.org/10.1038/s41398-021-01481-w2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rasmusson, Annica J.u Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)annijaco
2451 0a Toll-like receptor 4 methylation grade is linked to depressive symptom severity
264 c 2021-06-24
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
520 a This study explores potential associations between the methylation of promoter-associated CpG sites of the toll-like receptor (TLR)-family, plasma levels of pro-inflammatory proteins and depressive symptoms in young female psychiatric patients. Ratings of depressive symptoms and blood samples were obtained from 92 young women seeking psychiatric care. Methylation of 32 promoter-associated CpG sites in TLR1 to TLR10 was analysed using the Illumina Infinium Methylation EPIC BeadChip. Expression levels of 91 inflammatory proteins were determined by proximity extension assay. Statistical correlations between depressive state, TLR1-10 methylation and inflammatory proteins were investigated. Four additional cohorts were studied to evaluate the generalizability of the findings. In the discovery cohort, methylation grade of cg05429895 (TLR4) in blood was inversely correlated with depressive symptoms score in young adults. After correction for multiple testing, plasma levels of macrophage inflammatory protein 1 beta (MIP-1 beta/CCL4) were associated with both TLR4 methylation and depressive symptom severity. A similar inverse association between TLR4 methylation in blood and affective symptoms score was also found in a cohort of 148 both males and females (<40 years of age) from the Danish Twin Registry. These findings were not, however, replicated in three other external cohorts; which differed from the first two cohorts by a higher age and mixed ethnicities, thus limiting the generalizability of our findings. However, TLR4 methylation inversely correlated with TLR4 mRNA expression in the Danish Twin Study indicating a functional significance of methylation at this particular CpG. Higher depression scores in young Scandinavian adults was associated with decreased methylation of TLR4 in blood.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
7001 a Gallwitz, Maikeu Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)magal613
7001 a Soltanabadi, Bardiau Uppsala universitet,Cervenka: Psykiatri4 aut
7001 a Ciuculete, Diana-Mariau Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)diaci119
7001 a Mengel-From, Jonasu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.4 aut
7001 a Christensen, Kaareu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.;Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark.4 aut
7001 a Nygaard, Marianneu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.4 aut
7001 a Soerensen, Metteu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.;Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark.4 aut
7001 a Boström, Adrian,d 1990-u Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)adrbo331
7001 a Fredriksson, Robertu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)rfr20930
7001 a Freyhult, Eva,d 1979-u Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)evfre192
7001 a Mwinyi, Jessicau Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)jesmw847
7001 a Czamara, Darinau Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.4 aut
7001 a Binder, Elisabeth B.u Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.4 aut
7001 a Schiöth, Helgi B.u Uppsala universitet,Schiöth: Funktionell farmakologi,IM Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia.4 aut0 (Swepub:uu)helgschi
7001 a Cunningham, Janetu Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)janecunn
7102 a Uppsala universitetb Cervenka: Psykiatri4 org
7730 t Translational Psychiatryd : Springer Natureg 11q 11x 2158-3188
8564 u https://doi.org/10.1038/s41398-021-01481-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1595487/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41398-021-01481-w.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453041
8564 8u https://doi.org/10.1038/s41398-021-01481-w

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