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Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers

Beyer, K. (author)
Division of Pediatric Allergy and Immunology, Mount Sinai Medical Center, New York, NY, United States, Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States, Department of Pediatrics, Humboldt University, Berlin, Germany
Nickel, R. (author)
Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States, Department of Pediatrics, Humboldt University, Berlin, Germany
Freidhoff, L. (author)
Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States
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Björkstén, Bengt (author)
Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
Huang, S.-K. (author)
Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States
Barnes, K.C. (author)
Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States
MacDonald, S. (author)
Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States
Forster, J. (author)
Department of Pediatrics, University Hospitals, Freiburg, Germany
Zepp, F. (author)
Department of Pediatrics, University Hospitals, Mainz, Germany
Wahn, V. (author)
Department of Pediatrics, University Hospitals, Düsseldorf, Germany
Beaty, T.H. (author)
Department of Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, United States
Marsh, D.G. (author)
Division of Pediatric Allergy and Immunology, Mount Sinai Medical Center, New York, NY, United States, Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, United States
Wahn, U. (author)
Department of Pediatrics, Humboldt University, Berlin, Germany
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 (creator_code:org_t)
Elsevier BV, 2000
2000
English.
In: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 115:5, s. 906-908
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis, (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.

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