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Multiscale optical ...
Multiscale optical and optoacoustic imaging of amyloid-beta deposits in mice
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- Ni, Ruiqing (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
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- Chen, Zhenyue (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
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- Dean-Ben, Xose Luis (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
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visa fler...
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- Voigt, Fabian F. (författare)
- Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
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- Kirschenbaum, Daniel (författare)
- Univ Spital Zurich, Switzerland
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- Shi, Gloria (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland
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- Villois, Alessia (författare)
- Swiss Fed Inst Technol, Switzerland
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- Zhou, Quanyu (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
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- Crimi, Alessandro (författare)
- Univ Spital Zurich, Switzerland
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- Arosio, Paolo (författare)
- Swiss Fed Inst Technol, Switzerland
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- Nitsch, Roger M. (författare)
- Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
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- Nilsson, Peter, 1970- (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Aguzzi, Adriano (författare)
- Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Spital Zurich, Switzerland
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- Helmchen, Fritjof (författare)
- Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
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- Klohs, Jan (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
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- Razansky, Daniel (författare)
- Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
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(creator_code:org_t)
- 2022-07-14
- 2022
- Engelska.
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Ingår i: Nature Biomedical Engineering. - : NATURE PORTFOLIO. - 2157-846X. ; 6, s. 1031-1044
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess amyloid-beta deposits in transgenic mouse models of Alzheimers disease. Deposits of amyloid-beta (A beta) in the brains of rodents can be analysed by invasive intravital microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the resolution or molecular specificity to accurately characterize A beta pathologies. Here we show that large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess A beta deposits in transgenic mouse models of Alzheimers disease. We used fluorescent A beta-targeted probes (the luminescent conjugated oligothiophene HS-169 and the oxazine-derivative AOI987) to transcranially detect A beta deposits in the cortex of APP/PS1 and arcA beta mice with single-plaque resolution (8 mu m) and across the whole brain (including the hippocampus and the thalamus, which are inaccessible by conventional intravital microscopy) at sub-150 mu m resolutions. Two-photon microscopy, light-sheet microscopy and immunohistochemistry of brain-tissue sections confirmed the specificity and regional distributions of the deposits. High-resolution multiscale optical and optoacoustic imaging of A beta deposits across the entire brain in rodents thus facilitates the in vivo study of A beta accumulation by brain region and by animal age and strain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Ni, Ruiqing
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Chen, Zhenyue
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Dean-Ben, Xose L ...
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Voigt, Fabian F.
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Kirschenbaum, Da ...
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Shi, Gloria
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visa fler...
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Villois, Alessia
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Zhou, Quanyu
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Crimi, Alessandr ...
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Arosio, Paolo
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Nitsch, Roger M.
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Nilsson, Peter, ...
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Aguzzi, Adriano
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Helmchen, Fritjo ...
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Klohs, Jan
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Razansky, Daniel
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Neurovetenskaper
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Nature Biomedica ...
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Linköpings universitet