Sökning: WFRF:(Nordenskjöld Bo 1940 ) >
Breast cancer survi...
Breast cancer survival and incidence of second primary cancers after 30 years in a randomized study of two versus five years of adjuvant tamoxifen therapy
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- Nordenskjöld, Anna, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Fohlin, Helena (författare)
- Linköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Regionalt cancercentrum,Linköping Univ, Reg Canc Ctr Southeast Sweden, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.
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- Rosell, Johan (författare)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Region Östergötland, Regionalt cancercentrum,Linköping Univ, Reg Canc Ctr Southeast Sweden, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.
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- Bengtsson, Nils-Olof (författare)
- Umeå Univ Hosp, Dept Oncol, Umeå, Sweden.,Norrland University Hospital
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- Fornander, Tommy (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.
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- Hatschek, Thomas (författare)
- Karolinska Institute,Karolinska Inst, Sweden
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- Lindman, Henrik (författare)
- Uppsala Univ Hosp, Dept Oncol, Uppsala, Sweden,Uppsala University Hospital
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- Malmström, Per (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Rydén, Lisa (författare)
- Lund University,Lunds universitet,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast Cancer Surgery,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Sweden
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- Wallgren, Arne, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Stål, Olle (författare)
- Linköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.;Linköping Univ, Dept Oncol, Linköping, Sweden.
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- Nordenskjöld, Bo (författare)
- Linköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.;Linköping Univ, Dept Oncol, Linköping, Sweden.
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(creator_code:org_t)
- CHURCHILL LIVINGSTONE, 2023
- 2023
- Engelska.
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Ingår i: Breast. - : CHURCHILL LIVINGSTONE. - 0960-9776 .- 1532-3080. ; 71, s. 63-68
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen.Results: After 5 years of follow-up, when tamoxifen treatment was finished in both groups, until 15 years of follow-up, overall mortality (HR 0.80, 95% CI 0.72-0.90, p < 0.001), breast cancer mortality for all patients (HR 0.80, 95% CI 0.68-0.94, p = 0.006) and breast cancer mortality for patients with estrogen receptor positive disease (HR 0.67, 95% CI 0.55-0.83, p < 0.001) were significantly reduced in the five-year group as compared to the two-year group. After 15 years, the difference remained but did not further increase. In the five-year group, the incidence of contralateral breast cancer was gradually reduced during the entire period of observation. The incidence of lung cancer was also reduced in the five-year group. In contrast there was an increased endometrial cancer incidence in the five-year group and for those receiving 40 mg of tamoxifen this incidence was further increased.Conclusion: Three more years of tamoxifen therapy reduced the risk of breast cancer mortality. The difference was established during the first 15 years after randomization. Moreover, the incidence of contralateral breast cancer gradually decreased for 30 years. The incidence of lung cancer was reduced in the five-year group. In contrast the incidence of endometrial cancer was increased.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Breast
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- Av författaren/redakt...
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Nordenskjöld, An ...
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Fohlin, Helena
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Rosell, Johan
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Bengtsson, Nils- ...
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Fornander, Tommy
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Hatschek, Thomas
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visa fler...
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Lindman, Henrik
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Malmström, Per
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Rydén, Lisa
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Wallgren, Arne, ...
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Stål, Olle
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Nordenskjöld, Bo
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Breast
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Linköpings universitet
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Karolinska Institutet
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Uppsala universitet
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Lunds universitet
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Göteborgs universitet